Transdermal delivery of dextran using conductive microneedles assisted by iontophoresis
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 8075-8081 |
Journal / Publication | Journal of Materials Chemistry B |
Volume | 10 |
Issue number | 39 |
Online published | 12 Sept 2022 |
Publication status | Published - 12 Sept 2022 |
Link(s)
Abstract
The combination of microneedles (MNs) and iontophoresis (ITP) can enhance the drug penetration in the skin. We previously demonstrated the enhanced delivery of small molecule lidocaine in dentistry by the conductive MNs assisted by ITP. However, the delivery of macromolecules is yet to be explored for this strategy. This study fabricates conductive MNs with polyaniline and hyaluronic acid, which is combined with ITP to deliver dextran macromolecules. This combination improves the penetration of dextran molecules (3-5 kDa, 150 kDa, and 500 kDa) to a depth of around 1536 mu m in the agarose gel model. Compared to non-conductive MNs assisted by ITP or conductive MNs alone, conductive MNs assisted by ITP also improves dextran's penetration through the skin, fat, muscle, and cartilage. © The Royal Society of Chemistry 2022.
Research Area(s)
- POLYMERS
Citation Format(s)
Transdermal delivery of dextran using conductive microneedles assisted by iontophoresis. / Hu, Tianli; Zhang, Zhibiao; Xu, Chenjie.
In: Journal of Materials Chemistry B, Vol. 10, No. 39, 12.09.2022, p. 8075-8081.
In: Journal of Materials Chemistry B, Vol. 10, No. 39, 12.09.2022, p. 8075-8081.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review