Transcriptomic analysis of laribacter hongkongensis reveals adaptive response coupled with temperature

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

3 Scopus Citations
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Author(s)

  • Hon-Wai Law
  • Xuan Liu
  • Carmen O. K. Law
  • Qing Pan
  • Lin Gao
  • Lifeng Xiong
  • Susanna K. P. Lau
  • Patrick C. Y. Woo

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article numbere0169998
Journal / PublicationPLoS ONE
Volume12
Issue number1
Publication statusPublished - 1 Jan 2017

Link(s)

Abstract

Bacterial adaptation to different hosts requires transcriptomic alteration in response to the environmental conditions. Laribacter hongkongensis is a gram-negative, facultative anaerobic, urease-positive bacillus caused infections in liver cirrhosis patients and communityacquired gastroenteritis. It was also found in intestine from commonly consumed freshwater fishes and drinking water reservoirs. Since L. hongkongensis could survive as either fish or human pathogens, their survival mechanisms in two different habitats should be temperature-regulated and highly complex. Therefore, we performed transcriptomic analysis of L. hongkongensis at body temperatures of fish and human in order to elucidate the versatile adaptation mechanisms coupled with the temperatures. We identified numerous novel temperature-induced pathways involved in host pathogenesis, in addition to the shift of metabolic equilibriums and overexpression of stress-related proteins. Moreover, these pathways form a network that can be activated at a particular temperature, and change the physiology of the bacteria to adapt to the environments. In summary, the dynamic of transcriptomes in L. hongkongensis provides versatile strategies for the bacterial survival at different habitats and this alteration prepares the bacterium for the challenge of host immunity.

Research Area(s)

Citation Format(s)

Transcriptomic analysis of laribacter hongkongensis reveals adaptive response coupled with temperature. / Kong, Hoi-Kuan; Law, Hon-Wai; Liu, Xuan; Law, Carmen O. K.; Pan, Qing; Gao, Lin; Xiong, Lifeng; Lau, Susanna K. P.; Woo, Patrick C. Y.; Chi Kong Lau, Terrence.

In: PLoS ONE, Vol. 12, No. 1, e0169998, 01.01.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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