Tracking the changes of hippocampal population nonlinear dynamics in rats learning a memory-dependent task.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)22_Publication in policy or professional journal

12 Scopus Citations
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Author(s)

  • Dong Song
  • Anushka V Goonawardena
  • Sarah Bough
  • John Sesay
  • Robert E Hampson
  • Sam A Deadwyler
  • Theodore W Berger

Detail(s)

Original languageEnglish
Pages (from-to)3326-3329
Journal / PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Volume2011
Publication statusPublished - 2011
Externally publishedYes

Abstract

Neurobiological processes associated with learning are known to be highly nonlinear, dynamical, and time-varying. Characterizing the time-varying functional input-output properties of neural systems is a critical step to understand the neurobiological basis of learning. In this paper, we present a study on tracking of the changes of neural dynamics in rat hippocampus during learning of a memory-dependent delayed nonmatch-to-sample (DNMS) task. The rats were first trained to perform the DNMS task without a delay between the sample and response events. After reaching a performance level, they were subjected to the DNMS task with variable delays with a 5s mean duration. Spike trains were recorded from hippocampal CA3 (input) and CA1 (output) regions during all training sessions and constitute the input-output data for modeling. We applied the time-varying Generalized Laguerre-Volterra Model to study the changes of the CA3-CA1 nonlinear dynamics using these data. Result showed significant changes in the Volterra kernels after the introduction of delays. This result suggests that the CA3-CA1 nonlinear dynamics established in the initial training sessions underwent a functional reorganization as animals were learning to perform the task that now requires delays.

Citation Format(s)

Tracking the changes of hippocampal population nonlinear dynamics in rats learning a memory-dependent task. / Chan, Rosa H M; Song, Dong; Goonawardena, Anushka V; Bough, Sarah; Sesay, John; Hampson, Robert E; Deadwyler, Sam A; Berger, Theodore W.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Vol. 2011, 2011, p. 3326-3329.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)22_Publication in policy or professional journal