Projects per year
Abstract
We recently reported the recovery of a conjugative virulence plasmid, p15WZ-82_Vir, from a clinical Klebsiella variicola strain. In this study, we found that several new plasmid types were generated due to genetic rearrangement. Partial integration of plasmid p15WZ-82_Vir with existing plasmids such as resistance plasmids by different homologous recombination events was observable in three recipient strains. Such recombination events enable the formation of various types of mosaic plasmids simultaneously carrying virulence-encoding and antibiotic resistance-encoding genes as well as genes involved in plasmid conjugation, which promote transmission of various virulence-encoding and resistance-encoding elements among pathogens. Our data also suggest that these conjugative events may play an integral role in the development of novel mosaic plasmids, which is vital for plasmid evolution.
| Original language | English |
|---|---|
| Article number | e00140-20 |
| Journal | mSystems |
| Volume | 5 |
| Issue number | 4 |
| Online published | 14 Jul 2020 |
| DOIs | |
| Publication status | Published - Jul 2020 |
Research Keywords
- Conjugative
- Homologous recombination
- Hypervirulence plasmid
- Klebsiella pneumoniae
- Plasmid evolution
Publisher's Copyright Statement
- This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
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- 1 Finished
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CRF: Development of Novel Inhibitors Targeting the Resistance Mechanisms of Clinical Superbugs
CHEN, S. (Principal Investigator / Project Coordinator), CHAN, K. F. (Co-Principal Investigator), Hao, Q. (Co-Principal Investigator), LI, X. (Co-Principal Investigator) & MA, E.D.-L. (Co-Principal Investigator)
30/06/17 → 29/06/21
Project: Research