Total synthesis of teixobactin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

64 Scopus Citations
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Author(s)

  • Kang Jin
  • Iek Hou Sam
  • Kathy Hiu Laam Po
  • Du'an Lin
  • Ebrahim H. Ghazvini Zadeh
  • Yu Yuan
  • Xuechen Li

Detail(s)

Original languageEnglish
Article number12394
Journal / PublicationNature Communications
Volume7
Online published3 Aug 2016
Publication statusPublished - 2016
Externally publishedYes

Abstract

To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.

Citation Format(s)

Total synthesis of teixobactin. / Jin, Kang; Sam, Iek Hou; Po, Kathy Hiu Laam; Lin, Du'an; Ghazvini Zadeh, Ebrahim H.; Chen, Sheng; Yuan, Yu; Li, Xuechen.

In: Nature Communications, Vol. 7, 12394, 2016.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review