Total Synthesis of Mannopeptimycin β via β-Hydroxyenduracididine Ligation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jinzheng Wang
  • Du'an Lin
  • Ming Liu
  • Han Liu
  • Pilar Blasco
  • Zhenquan Sun
  • Xuechen Li

Detail(s)

Original languageEnglish
Pages (from-to)12784–12790
Journal / PublicationJournal of the American Chemical Society
Volume143
Issue number32
Online published5 Aug 2021
Publication statusPublished - 18 Aug 2021

Abstract

Nonribosomal peptide synthesis in bacteria has endowed cyclic peptides with fascinating structural complexity via incorporating nonproteinogenic amino acids. These bioactive cyclic peptides provide interesting structural motifs for exploring total synthesis and medicinal chemistry studies. Cyclic glycopeptide mannopeptimycins exhibit antibacterial activity against antibiotic-resistant Gram-positive pathogens and act as the lipid II binder to stop bacterial cell wall biosynthesis. Here, we report a strategy streamlining solution phase-solid phase synthesis and chemical ligation-mediated peptide cyclization for the total synthesis of mannopeptimycin β.

Citation Format(s)

Total Synthesis of Mannopeptimycin β via β-Hydroxyenduracididine Ligation. / Wang, Jinzheng; Lin, Du'an; Liu, Ming; Liu, Han; Blasco, Pilar; Sun, Zhenquan; Cheung, Yan Chu; Chen, Sheng; Li, Xuechen.

In: Journal of the American Chemical Society, Vol. 143, No. 32, 18.08.2021, p. 12784–12790.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review