Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile

Lea Radtke; Matthieu Willot; Hongyan Sun; Slava Ziegler; Stephanie Sauerland; Carsten Strohmann; Roland Fröhlich; Peter Habenberger; Herbert Waldmann; Mathias Christmann

doi:10.1002/anie.201007790

Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile

Lea Radtke
, Matthieu Willot
, Hongyan Sun
, Slava Ziegler
, Stephanie Sauerland
, Carsten Strohmann
, Roland Fröhlich
, Peter Habenberger
, Herbert Waldmann
, Mathias Christmann^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

80 Citations (Scopus)

Abstract

The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	3998-4002
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	17
DOIs	https://doi.org/10.1002/anie.201007790
Publication status	Published - 18 Apr 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

guaianes
renal cancer
structure-activity relationships
terpenes
total synthesis

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10.1002/anie.201007790

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@article{8edad72a21ea453a944bc45a55e61a04,

title = "Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile",

abstract = "The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. {\textcopyright} 2011 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

keywords = "guaianes, renal cancer, structure-activity relationships, terpenes, total synthesis",

author = "Lea Radtke and Matthieu Willot and Hongyan Sun and Slava Ziegler and Stephanie Sauerland and Carsten Strohmann and Roland Fr{\"o}hlich and Peter Habenberger and Herbert Waldmann and Mathias Christmann",

year = "2011",

month = apr,

day = "18",

doi = "10.1002/anie.201007790",

language = "English",

volume = "50",

pages = "3998--4002",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley \& Sons",

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}

Radtke, L, Willot, M, Sun, H, Ziegler, S, Sauerland, S, Strohmann, C, Fröhlich, R, Habenberger, P, Waldmann, H & Christmann, M 2011, 'Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile', Angewandte Chemie - International Edition, vol. 50, no. 17, pp. 3998-4002. https://doi.org/10.1002/anie.201007790

Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile. / Radtke, Lea; Willot, Matthieu; Sun, Hongyan et al.
In: Angewandte Chemie - International Edition, Vol. 50, No. 17, 18.04.2011, p. 3998-4002.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Total synthesis and biological evaluation of (-)-englerin A and B

T2 - Synthesis of analogues with improved activity profile

AU - Radtke, Lea

AU - Willot, Matthieu

AU - Sun, Hongyan

AU - Ziegler, Slava

AU - Sauerland, Stephanie

AU - Strohmann, Carsten

AU - Fröhlich, Roland

AU - Habenberger, Peter

AU - Waldmann, Herbert

AU - Christmann, Mathias

PY - 2011/4/18

Y1 - 2011/4/18

N2 - The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - guaianes

KW - renal cancer

KW - structure-activity relationships

KW - terpenes

KW - total synthesis

UR - https://www.scopus.com/pages/publications/79954576625

UR - https://www.scopus.com/pages/publications/79954576625#tab=impact

U2 - 10.1002/anie.201007790

DO - 10.1002/anie.201007790

M3 - RGC 21 - Publication in refereed journal

C2 - 21472928

SN - 1433-7851

VL - 50

SP - 3998

EP - 4002

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 17

ER -

Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile

Abstract

UN SDGs

Research Keywords

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