Topology in Biological Piezoelectric Materials

Chen Chen; Yanhu Zhang; Yi Zheng; Yi Zhang; Hongyi Liu; Jiang Wu; Liang Yang; Zhengbao Yang

doi:10.1002/adma.202500466

Topology in Biological Piezoelectric Materials

Chen Chen, Yanhu Zhang^*, Yi Zheng, Yi Zhang, Hongyi Liu, Jiang Wu, Liang Yang, Zhengbao Yang^*

^*Corresponding author for this work

Department of Mechanical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

3 Citations (Scopus)

8 Downloads (CityUHK Scholars)

Abstract

Topology is fundamental in determining the properties and functions of biological piezoelectric materials by influencing service performances across multiple scales, from nanoscale molecular arrangements to macroscopic assembly structures. At each scale, topology governs electrical, mechanical, and biological behaviors, facilitating multifunctional integration and multi-field coupling advances. Recent progress demonstrates the potential of topological optimization to enhance piezoelectric coefficients and enable complex functionalities. Strategies such as multi-scale design, machine learning-guided optimization, and precision fabrication techniques are being explored to address persistent challenges, including limited energy conversion efficiency, long-term stability, and biocompatibility. Critical applications include health monitoring, biosensing, energy harvesting, and disease treatment, highlighting opportunities and unresolved technical bottlenecks. Future research directions are discussed to present theoretical insights and practical pathways to the development of biological piezoelectric materials. © 2025 The Author(s). Advanced Materials published by Wiley-VCH GmbH

Original language	English
Article number	2500466
Journal	Advanced Materials
Volume	37
Issue number	32
Online published	4 Jun 2025
DOIs	https://doi.org/10.1002/adma.202500466
Publication status	Published - 14 Aug 2025

Funding

This work was supported by the National Natural Science Foundation of China (51705210), Jiangsu Province Post-Doctoral Research Funding Scheme (2019K195), and Shenzhen-Hongkong Joint Innovation Project (SGDX20190919102801693), the Hong Kong University of Science and Technology, and the Innovation and Technology Fund (Project No. MHP/013/23) from Innovation and Technology Commission of Hong Kong Special Administrative Region.

Research Keywords

biomaterials
energy conversion
energy harvesting
piezoelectric
sensor

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 4.0. https://creativecommons.org/licenses/by-nc/4.0/

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AU - Chen, Chen

AU - Zhang, Yanhu

AU - Zheng, Yi

AU - Zhang, Yi

AU - Liu, Hongyi

AU - Wu, Jiang

AU - Yang, Liang

AU - Yang, Zhengbao

PY - 2025/8/14

Y1 - 2025/8/14

N2 - Topology is fundamental in determining the properties and functions of biological piezoelectric materials by influencing service performances across multiple scales, from nanoscale molecular arrangements to macroscopic assembly structures. At each scale, topology governs electrical, mechanical, and biological behaviors, facilitating multifunctional integration and multi-field coupling advances. Recent progress demonstrates the potential of topological optimization to enhance piezoelectric coefficients and enable complex functionalities. Strategies such as multi-scale design, machine learning-guided optimization, and precision fabrication techniques are being explored to address persistent challenges, including limited energy conversion efficiency, long-term stability, and biocompatibility. Critical applications include health monitoring, biosensing, energy harvesting, and disease treatment, highlighting opportunities and unresolved technical bottlenecks. Future research directions are discussed to present theoretical insights and practical pathways to the development of biological piezoelectric materials. © 2025 The Author(s). Advanced Materials published by Wiley-VCH GmbH

AB - Topology is fundamental in determining the properties and functions of biological piezoelectric materials by influencing service performances across multiple scales, from nanoscale molecular arrangements to macroscopic assembly structures. At each scale, topology governs electrical, mechanical, and biological behaviors, facilitating multifunctional integration and multi-field coupling advances. Recent progress demonstrates the potential of topological optimization to enhance piezoelectric coefficients and enable complex functionalities. Strategies such as multi-scale design, machine learning-guided optimization, and precision fabrication techniques are being explored to address persistent challenges, including limited energy conversion efficiency, long-term stability, and biocompatibility. Critical applications include health monitoring, biosensing, energy harvesting, and disease treatment, highlighting opportunities and unresolved technical bottlenecks. Future research directions are discussed to present theoretical insights and practical pathways to the development of biological piezoelectric materials. © 2025 The Author(s). Advanced Materials published by Wiley-VCH GmbH

KW - biomaterials

KW - energy conversion

KW - energy harvesting

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KW - sensor

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Topology in Biological Piezoelectric Materials

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Funding

Research Keywords

Publisher's Copyright Statement

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