Titania coated upconversion nanoparticles for near-infrared light triggered photodynamic therapy

Sasidharan Swarnalatha Lucky, Niagara Muhammad Idris, Zhengquan Li, Kai Huang, Khee Chee Soo, Yong Zhang*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

345 Citations (Scopus)

Abstract

Because of the limited penetration depth of visible light that generally excites most of the available photosensitizers (PSs), conventional photodynamic therapy (PDT) is limited to the treatment of superficial and flat lesions. Recently, the application of deep penetrating near-infrared (NIR) light excitable upconversion nanoparticles (UCNs) in conjunction with PDT has shown to have clear potential in the treatment of solid tumors due to its ability to penetrate thick tissue. However, various constructs developed so far have certain limitations such as poor or unstable PS loading, reducing their therapeutic efficacy and limiting their application to solution or cell-based studies. In this work, we present a method to fabricate uniform core-shell structured nanoconstruct with a thin layer of photocatalyst or PS-titanium dioxide (TiO2) stably coated on individual UCN core. Our design allows controllable and highly reproducible PS loading, preventing any leakage of PS compared to previously developed nanoconstructs, thus ensuring repeatable PDT results. Further surface modification of the developed nanoconstructs with polyethylene glycol (PEG) rendered them biocompatible, demonstrating good therapeutic efficacy both in vitro and in vivo. © 2015 American Chemical Society.
Original languageEnglish
Pages (from-to)191-205
JournalACS Nano
Volume9
Issue number1
DOIs
Publication statusPublished - 27 Jan 2015
Externally publishedYes

Bibliographical note

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Research Keywords

  • cancer
  • near-infrared
  • photodynamic therapy
  • titanium dioxide
  • upconversion nanoparticles

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