Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Wei Shi
  • Feng-Xian Zhang
  • Guan-Jiu Hu
  • Ying-Qun Hao
  • Xiao-Wei Zhang
  • And 5 others
  • Hong-Ling Liu
  • Si Wei
  • Xin-Ru Wang
  • John P. Giesy
  • Hong-Xia Yu

Detail(s)

Original languageEnglish
Pages (from-to)117-123
Journal / PublicationEnvironment International
Volume42
Issue number1
Publication statusPublished - Jul 2012

Abstract

Thyroid hormone disrupting compounds in water sources is a concern. Thyroid hormone (TH) agonist and antagonist activities of water sources from the Yangtze River, Huaihe River, Taihu Lake and ground water in the Yangtze River Delta region were evaluated by use of a TH reporter gene assay based on the green monkey kidney fibroblast (CV-1). While weak TH receptor (TR) agonist potency was observed in only one of 15 water sources, antagonist potency was present in most of the water sources. TR antagonist equivalents could be explained by the presence of dibutyl phthalate (DBP), with concentrations ranging from 2.8×10 1 to 1.6×10 3μg DBP /L (ATR-EQ 50s). None of the ground waters exhibited TH agonist potencies while all of the samples from Taihu Lake displayed notable TR antagonist potencies. To identify the responsible thyroid active compounds, instrumental analysis was conducted to measure a list of potential thyroid-disrupting chemicals, including organochlorine (OC) pesticides and phthalate esters. Combining the results of the instrumental analysis with those of the bioassay, DBP was determined to account for 17% to 144% of ATR-EQ 50s in water sources. Furthermore, ATR-EQ 20-80 ranges for TR antagonist activities indicated that samples from locations WX-1 and WX-2 posed the greatest health concern and the associated uncertainty may warrant further investigation. © 2011 Elsevier Ltd.

Research Area(s)

  • Agonist equivalents, Antagonist equivalents, ATR-EQ 20-80 range, Dibutyl phthalate, Human risk, Reporter gene assay

Citation Format(s)

Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. / Shi, Wei; Zhang, Feng-Xian; Hu, Guan-Jiu; Hao, Ying-Qun; Zhang, Xiao-Wei; Liu, Hong-Ling; Wei, Si; Wang, Xin-Ru; Giesy, John P.; Yu, Hong-Xia.

In: Environment International, Vol. 42, No. 1, 07.2012, p. 117-123.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal