Three-dimensional super-resolution morphology by near-field assisted white-light interferometry

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

33 Scopus Citations
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Author(s)

  • Feifei Wang
  • Lianqing Liu
  • Peng Yu
  • Zhu Liu
  • Haibo Yu
  • Yuechao Wang

Detail(s)

Original languageEnglish
Article number24703
Journal / PublicationScientific Reports
Volume6
Publication statusPublished - 22 Apr 2016

Link(s)

Abstract

Recent developments in far-field fluorescent microscopy have enabled nanoscale imaging of biological entities by ingenious applications of fluorescent probes. For non-fluorescence applications, however, scanning probe microscopy still remains one of the most commonly used methods to "image"" nanoscale features in all three dimensions, despite its limited throughput and invasiveness to scanned samples. Here, we propose a time-efficient three-dimensional super-resolution microscopy method: near-field assisted white light interferometry (NFWLI). This method takes advantage of topography acquisition using white-light interferometry and lateral near-field imaging via a microsphere superlens. The ability to discern structures in central processing units (CPUs) with minimum feature sizes of approximately 50 nm in the lateral dimensions and approximately 10 nm in the axial dimension within 25 s (40 times faster than atomic force microscopes) was demonstrated. We elaborate in this paper the principles of NFWLI and demonstrate its potential for becoming a practical method for high-speed and non-toxic three-dimensional nanoscale imaging.

Research Area(s)

Citation Format(s)

Three-dimensional super-resolution morphology by near-field assisted white-light interferometry. / Wang, Feifei; Liu, Lianqing; Yu, Peng; Liu, Zhu; Yu, Haibo; Wang, Yuechao; Li, Wen Jung.

In: Scientific Reports, Vol. 6, 24703, 22.04.2016.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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