Three-dimensional segmentation of three-dimensional ultrasound carotid atherosclerosis using sparse field level sets

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

35 Scopus Citations
View graph of relations

Author(s)

  • E. Ukwatta
  • J. Yuan
  • D. Buchanan
  • J. Awad
  • W. Qiu
  • G. Parraga
  • A. Fenster

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number52903
Journal / PublicationMedical Physics
Volume40
Issue number5
Publication statusPublished - May 2013

Abstract

Purpose: Three-dimensional ultrasound (3DUS) vessel wall volume (VWV) provides a 3D measurement of carotid artery wall remodeling and atherosclerotic plaque and is sensitive to temporal changes of carotid plaque burden. Unfortunately, although 3DUS VWV provides many advantages compared to measurements of arterial wall thickening or plaque alone, it is still not widely used in research or clinical practice because of the inordinate amount of time required to train observers and to generate 3DUS VWV measurements. In this regard, semiautomated methods for segmentation of the carotid media-adventitia boundary (MAB) and the lumen-intima boundary (LIB) would greatly improve the time to train observers and for them to generate 3DUS VWV measurements with high reproducibility. Methods: The authors describe a 3D algorithm based on a modified sparse field level set method for segmenting the MAB and LIB of the common carotid artery (CCA) from 3DUS images. To the authors' knowledge, the proposed algorithm is the first direct 3D segmentation method, which has been validated for segmenting both the carotid MAB and the LIB from 3DUS images for the purpose of computing VWV. Initialization of the algorithm requires the observer to choose anchor points on each boundary on a set of transverse slices with a user-specified interslice distance (ISD), in which larger ISD requires fewer user interactions than smaller ISD. To address the challenges of the MAB and LIB segmentations from 3DUS images, the authors integrated regional- and boundary-based image statistics, expert initializations, and anatomically motivated boundary separation into the segmentation. The MAB is segmented by incorporating local region-based image information, image gradients, and the anchor points provided by the observer. Moreover, a local smoothness term is utilized to maintain the smooth surface of the MAB. The LIB is segmented by constraining its evolution using the already segmented surface of the MAB, in addition to the global region-based information and the anchor points. The algorithm-generated surfaces were sliced and evaluated with respect to manual segmentations on a slice-by-slice basis using 21 3DUS images. Results: The authors used ISD of 1, 2, 3, 4, and 10 mm for algorithm initialization to generate segmentation results. The algorithm-generated accuracy and intraobserver variability results are comparable to the previous methods, but with fewer user interactions. For example, for the ISD of 3 mm, the algorithm yielded an average Dice coefficient of 94.4 ± 2.2 and 90.6 ± 5.0 for the MAB and LIB and the coefficient of variation of 6.8 for computing the VWV of the CCA, while requiring only 1.72 min (vs 8.3 min for manual segmentation) for a 3DUS image. Conclusions: The proposed 3D semiautomated segmentation algorithm yielded high-accuracy and high-repeatability, while reducing the expert interaction required for initializing the algorithm than the previous 2D methods. © 2013 American Association of Physicists in Medicine.

Research Area(s)

  • 3D carotid segmentation, 3DUS images, carotid atherosclerosis, intima-media thickness, sparse field level set, vessel wall volume

Citation Format(s)

Three-dimensional segmentation of three-dimensional ultrasound carotid atherosclerosis using sparse field level sets. / Ukwatta, E.; Yuan, J.; Buchanan, D. et al.
In: Medical Physics, Vol. 40, No. 5, 52903, 05.2013.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review