Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea

Lu Wen; Xiaoling Cai; Fang Xu; Zhigang She; Wing Lai Chan; L. L P Vrijmoed; E. B G Jones; Yongcheng Lin

doi:10.1021/jo802096q

Author(s)

Lu Wen
Xiaoling Cai
Fang Xu
Zhigang She
Wing Lai Chan
And 3 others

L. L P Vrijmoed
E. B G Jones
Yongcheng Lin

Detail(s)

Original language	English
Pages (from-to)	1093-1098
Journal / Publication	Journal of Organic Chemistry
Volume	74
Issue number	3
Publication status	Published - 6 Feb 2009

Link(s)

DOI	DOI https://doi.org/10.1021/jo802096q Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-64549098238&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(0a493efe-95cb-4789-821e-71c1b4cacecf).html

Abstract

Three metabolites, sporothrins A, B, and C (1-3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8- Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis. ©2009 American Chemical Society.

Citation Format(s)

[ RIS ] [ BibTeX ]

Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea. / Wen, Lu; Cai, Xiaoling; Xu, Fang et al.

In: Journal of Organic Chemistry, Vol. 74, No. 3, 06.02.2009, p. 1093-1098.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Wen, L, Cai, X, Xu, F, She, Z, Chan, WL, Vrijmoed, LLP, Jones, EBG & Lin, Y 2009, 'Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea', Journal of Organic Chemistry, vol. 74, no. 3, pp. 1093-1098. https://doi.org/10.1021/jo802096q

Wen, L., Cai, X., Xu, F., She, Z., Chan, W. L., Vrijmoed, L. L. P., Jones, E. B. G., & Lin, Y. (2009). Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea. Journal of Organic Chemistry, 74(3), 1093-1098. https://doi.org/10.1021/jo802096q

Wen L, Cai X, Xu F, She Z, Chan WL, Vrijmoed LLP et al. Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea. Journal of Organic Chemistry. 2009 Feb 6;74(3):1093-1098. doi: 10.1021/jo802096q

Wen, Lu ; Cai, Xiaoling ; Xu, Fang et al. / Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea. In: Journal of Organic Chemistry. 2009 ; Vol. 74, No. 3. pp. 1093-1098.