Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Lu Wen
  • Xiaoling Cai
  • Fang Xu
  • Zhigang She
  • Wing Lai Chan
  • And 3 others
  • L. L P Vrijmoed
  • E. B G Jones
  • Yongcheng Lin

Detail(s)

Original languageEnglish
Pages (from-to)1093-1098
Journal / PublicationJournal of Organic Chemistry
Volume74
Issue number3
Publication statusPublished - 6 Feb 2009

Abstract

Three metabolites, sporothrins A, B, and C (1-3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8- Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis. ©2009 American Chemical Society.

Citation Format(s)

Three metabolites from the mangrove endophytic fungus sporothrix sp. (#4335) from the south china sea. / Wen, Lu; Cai, Xiaoling; Xu, Fang; She, Zhigang; Chan, Wing Lai; Vrijmoed, L. L P; Jones, E. B G; Lin, Yongcheng.

In: Journal of Organic Chemistry, Vol. 74, No. 3, 06.02.2009, p. 1093-1098.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal