Thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) microgels for controlled drug release

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Penghui Li
  • Ruizhen Xu
  • Wenhao Wang
  • Xiaolong Li
  • Zushun Xu
  • Kelvin W.K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)251-255
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume101
Publication statusPublished - 1 Jan 2013

Abstract

A new type of thermosensitive microgels with epoxy functional groups is designed and synthesized for drug delivery. The thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) (designated as P(NIPAM-co-GMA)) microgels are prepared by an emulsifier-free emulsion polymerization method and the chemical composition of the copolymer is determined by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H NMR). The lower critical solution temperature (LCST) of the microgels is 32°C based on the transmittance changes at 500nm monitored by UV/visible spectrophotometry. The hydrodynamic diameter and morphology of the microgel particles are examined by dynamic light scattering (DLS) and scanning electron microscopy (SEM), respectively. The drug release properties determined using 5-FU as the drug model in vitro reveal temperature dependence and low cytotoxicity. The thermosensitive microgels have large potential as targeted anti-cancer drug carriers. © 2012 Elsevier B.V..

Research Area(s)

  • Drug delivery, Epoxy groups, Microgels, Thermosensitive

Citation Format(s)

Thermosensitive poly(N-isopropylacrylamide-co-glycidyl methacrylate) microgels for controlled drug release. / Li, Penghui; Xu, Ruizhen; Wang, Wenhao; Li, Xiaolong; Xu, Zushun; Yeung, Kelvin W.K.; Chu, Paul K.

In: Colloids and Surfaces B: Biointerfaces, Vol. 101, 01.01.2013, p. 251-255.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review