Abstract
Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 14645-14648 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 97 |
| Online published | 11 Nov 2019 |
| DOIs | |
| Publication status | Published - 18 Dec 2019 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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