TY - JOUR
T1 - Thermoresponsive drug delivery to mitochondria in vivo
AU - Ruan, Lifo
AU - Zhou, Mengxue
AU - Chen, Jun
AU - Huang, Hui
AU - Zhang, Jiayu
AU - Sun, Hongyan
AU - Chai, Zhifang
AU - Hu, Yi
PY - 2019/12/18
Y1 - 2019/12/18
N2 - Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.
AB - Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85076013720&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85076013720&origin=recordpage
U2 - 10.1039/c9cc07538k
DO - 10.1039/c9cc07538k
M3 - RGC 21 - Publication in refereed journal
C2 - 31746851
SN - 1359-7345
VL - 55
SP - 14645
EP - 14648
JO - Chemical Communications
JF - Chemical Communications
IS - 97
ER -
