Thermoresponsive drug delivery to mitochondria in vivo
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 14645-14648 |
Journal / Publication | Chemical Communications |
Volume | 55 |
Issue number | 97 |
Online published | 11 Nov 2019 |
Publication status | Published - 18 Dec 2019 |
Link(s)
Abstract
Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.
Research Area(s)
Citation Format(s)
Thermoresponsive drug delivery to mitochondria in vivo. / Ruan, Lifo; Zhou, Mengxue; Chen, Jun et al.
In: Chemical Communications, Vol. 55, No. 97, 18.12.2019, p. 14645-14648.
In: Chemical Communications, Vol. 55, No. 97, 18.12.2019, p. 14645-14648.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review