Therapeutic Interventions of Gut-Brain Axis as Novel Strategies for Treatment of Alcohol Use Disorder Associated Cognitive and Mood Dysfunction

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

13 Scopus Citations
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Author(s)

  • Xin Li
  • Le-Mei Chen
  • Gajendra Kumar
  • Shan-Jin Zhang
  • Quan-hai Zhong
  • And 5 others
  • Hong-Yan Zhang
  • Guan Gui
  • Lv-Le Wu
  • Hui-Zhen Fan
  • Jian-Wen Sheng

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number820106
Journal / PublicationFrontiers in Neuroscience
Volume16
Online published2 Feb 2022
Publication statusPublished - Feb 2022

Link(s)

Abstract

Alcohol use disorders (AUD) is characterized by persistent or intermittent alcohol cravings and compulsive drinking. The functional changes in the central nervous system (CNS) after alcohol consumption are alcohol-associated cognitive impairment and mood disorders, which are major health issues reported in AUDs. Studies have shown that transferring the intestinal microbiota from AUDs patients to germ-free animals causes learning and memory dysfunction, depression and anxiety-like behavior, indicating the vital role of intestinal microbiota in development of neuropsychiatric disorders in AUD. Intestinal flora composition of AUD patients are significantly different from normal people, suggesting that intestinal flora imbalance orchestrate the development of neuropsychiatric disorders in AUD. Studies suggests that gut microbiome links bidirectional signaling network of the enteric nervous system (ENS) to central nervous system (CNS), forming gut-microbe-brain axis (brain-gut axis). In this review, we discussed pathogenesis and possible treatment of AUD-induced cognitive deficits, anxiety, and depression disorders. Further, we described the mechanism of intestinal flora imbalance and dysfunction of hippocampus-amygdala-frontal cortex (gut-limbic circuit system dysfunction). Therefore, we postulate therapeutic interventions of gut-brain axis as novel strategies for treatment of AUD-induced neuropsychiatric disorders.

Research Area(s)

  • alcohol use disorder (AUD)s, brain-gut axis, cognitive impairment, hippocampus-amygdala- frontal cortex circuit, mood disorder

Citation Format(s)

Therapeutic Interventions of Gut-Brain Axis as Novel Strategies for Treatment of Alcohol Use Disorder Associated Cognitive and Mood Dysfunction. / Li, Xin; Chen, Le-Mei; Kumar, Gajendra et al.
In: Frontiers in Neuroscience, Vol. 16, 820106, 02.2022.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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