TY - JOUR
T1 - Therapeutic Deep Brain Stimulation in Parkinsonian Rats Directly Influences Motor Cortex
AU - Li, Qian
AU - Ke, Ya
AU - Chan, Danny C.W.
AU - Qian, Zhong-Ming
AU - Yung, Ken K.L.
AU - Ko, Ho
AU - Arbuthnott, Gordon W.
AU - Yung, Wing-Ho
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2012/12/6
Y1 - 2012/12/6
N2 - Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimulation, it had been assumed that its action is on the nucleus itself. By means of simultaneous recordings of the firing activities from populations of neurons and the local field potentials in the motor cortex of freely moving Parkinsonian rats, this study casts doubt on this assumption. Instead, we found evidence that the corrective action is upon the cortex, where stochastic antidromic spikes originating from the STN directly modify the firing probability of the corticofugal projection neurons, destroy the dominance of beta rhythm, and thus restore motor control to the subjects, be they patients or rodents.
AB - Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimulation, it had been assumed that its action is on the nucleus itself. By means of simultaneous recordings of the firing activities from populations of neurons and the local field potentials in the motor cortex of freely moving Parkinsonian rats, this study casts doubt on this assumption. Instead, we found evidence that the corrective action is upon the cortex, where stochastic antidromic spikes originating from the STN directly modify the firing probability of the corticofugal projection neurons, destroy the dominance of beta rhythm, and thus restore motor control to the subjects, be they patients or rodents.
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U2 - 10.1016/j.neuron.2012.09.032
DO - 10.1016/j.neuron.2012.09.032
M3 - RGC 21 - Publication in refereed journal
C2 - 23217750
SN - 0896-6273
VL - 76
SP - 1030
EP - 1041
JO - Neuron
JF - Neuron
IS - 5
ER -