Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems

Xiaowei Zhou; Ling Chen; Chun-Yu Tse; Trevor B. Penney; Nanguang Chen

doi:10.1109/PGC.2012.6458116

Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems

Xiaowei Zhou, Ling Chen, Chun-Yu Tse, Trevor B. Penney, Nanguang Chen^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

2 Citations (Scopus)

Abstract

The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system. © 2012 IEEE.

Original language	English
Title of host publication	2012 Photonics Global Conference (PGC)
Publisher	IEEE
ISBN (Electronic)	978-1-4673-2516-5
ISBN (Print)	978-1-4673-2513-4
DOIs	https://doi.org/10.1109/PGC.2012.6458116
Publication status	Published - Dec 2012
Externally published	Yes
Event	2012 Photonics Global Conference, PGC 2012 - Singapore, Singapore Duration: 13 Dec 2012 → 16 Dec 2012

Conference

Conference	2012 Photonics Global Conference, PGC 2012
Place	Singapore
City	Singapore
Period	13/12/12 → 16/12/12

Research Keywords

DOT systems
Near infrared light
penetration depth
tissue spatial sensitivity

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title = "Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems",

abstract = "The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system. {\textcopyright} 2012 IEEE.",

keywords = "DOT systems, Near infrared light, penetration depth, tissue spatial sensitivity, DOT systems, Near infrared light, penetration depth, tissue spatial sensitivity, DOT systems, Near infrared light, penetration depth, tissue spatial sensitivity",

author = "Xiaowei Zhou and Ling Chen and Chun-Yu Tse and Penney, {Trevor B.} and Nanguang Chen",

year = "2012",

month = dec,

doi = "10.1109/PGC.2012.6458116",

language = "English",

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publisher = "IEEE",

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note = "2012 Photonics Global Conference, PGC 2012 ; Conference date: 13-12-2012 Through 16-12-2012",

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TY - GEN

T1 - Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems

AU - Zhou, Xiaowei

AU - Chen, Ling

AU - Tse, Chun-Yu

AU - Penney, Trevor B.

AU - Chen, Nanguang

PY - 2012/12

Y1 - 2012/12

N2 - The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system. © 2012 IEEE.

AB - The optical path of near-infrared light propagation in multi-layer brain models was investigated by theoretical and computational analysis for three DOT systems. The brain models are comprised a three-layer slab or three-layer semi-sphere intersected by a same size three-layer slab. In each model, the light penetration depths and the shapes of light paths for different source and detector pairs were analyzed with a numerical diffusion forward model based on the finite element method. The simulation results revealed that the light path was affected by source and detector distance, and varied in the different brain models. Specifically, the effective penetration depths were different for the different DOT systems and deeper penetration depth was observed using a fast time-domain DOT system. © 2012 IEEE.

KW - DOT systems

KW - Near infrared light

KW - penetration depth

KW - tissue spatial sensitivity

KW - DOT systems

KW - Near infrared light

KW - penetration depth

KW - tissue spatial sensitivity

KW - DOT systems

KW - Near infrared light

KW - penetration depth

KW - tissue spatial sensitivity

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DO - 10.1109/PGC.2012.6458116

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 978-1-4673-2513-4

BT - 2012 Photonics Global Conference (PGC)

PB - IEEE

T2 - 2012 Photonics Global Conference, PGC 2012

Y2 - 13 December 2012 through 16 December 2012

ER -

Theoretical investigation of near-infrared light path in multi-layer brain models for three DOT systems

Abstract

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Research Keywords

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