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The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

  • Pui-Chi Lo
  • , M. Salomé Rodríguez-Morgade
  • , Ravindra K. Pandey*
  • , Dennis K. P. Ng*
  • , Tomás Torres*
  • , Fabienne Dumoulin*
  • *Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Abstract

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.
Original languageEnglish
Pages (from-to)1041-1056
JournalChemical Society Reviews
Volume49
Issue number4
Online published17 Dec 2019
DOIs
Publication statusPublished - 21 Feb 2020

Bibliographical note

Information for this record is supplemented by the author(s) concerned.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Research Keywords

  • Phthalocyanine
  • Photodynamic therapy

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