The tiger genome and comparative analysis with lion and snow leopard genomes

Yun Sung Cho; Li Hu; Haolong Hou; Hang Lee; Jiaohui Xu; Soowhan Kwon; Sukhun Oh; Hak-Min Kim; Sungwoong Jho; Sangsoo Kim; Young-Ah Shin; Byung Chul Kim; Hyunmin Kim; Chang-Uk Kim; Shu-Jin Luo; Warren E. Johnson; Klaus-Peter Koepfli; Anne Schmidt-Küntzel; Jason A. Turner; Laurie Marker; Cindy Harper; Susan M. Miller; Wilhelm Jacobs; Laura D. Bertola; Tae Hyung Kim; Sunghoon Lee; Qian Zhou; Hyun-Ju Jung; Xiao Xu; Priyvrat Gadhvi; Pengwei Xu; Yingqi Xiong; Yadan Luo; Shengkai Pan; Caiyun Gou; Xiuhui Chu; Jilin Zhang; Sanyang Liu; Jing He; Ying Chen; Linfeng Yang; Yulan Yang; Jiaju He; Sha Liu; Junyi Wang; Chul Hong Kim; Hwanjong Kwak; Jong-Soo Kim; Seungwoo Hwang; Junsu Ko; Chang-Bae Kim; Sangtae Kim; Damdin Bayarlkhagva; Woon Kee Paek; Seong-Jin Kim; Stephen J. O'Brien; Jun Wang; Jong Bhak

doi:10.1038/ncomms3433

The tiger genome and comparative analysis with lion and snow leopard genomes

Yun Sung Cho
, Li Hu
, Haolong Hou
, Hang Lee
, Jiaohui Xu
, Soowhan Kwon
, Sukhun Oh
, Hak-Min Kim
, Sungwoong Jho
, Sangsoo Kim
, Young-Ah Shin
, Byung Chul Kim
, Hyunmin Kim
, Chang-Uk Kim
, Shu-Jin Luo
, Warren E. Johnson
, Klaus-Peter Koepfli
, Anne Schmidt-Küntzel
, Jason A. Turner
, Laurie Marker

Cindy Harper, Susan M. Miller, Wilhelm Jacobs, Laura D. Bertola, Tae Hyung Kim, Sunghoon Lee, Qian Zhou, Hyun-Ju Jung, Xiao Xu, Priyvrat Gadhvi, Pengwei Xu, Yingqi Xiong, Yadan Luo, Shengkai Pan, Caiyun Gou, Xiuhui Chu, Jilin Zhang, Sanyang Liu, Jing He, Ying Chen, Linfeng Yang, Yulan Yang, Jiaju He, Sha Liu, Junyi Wang, Chul Hong Kim, Hwanjong Kwak, Jong-Soo Kim, Seungwoo Hwang, Junsu Ko, Chang-Bae Kim, Sangtae Kim, Damdin Bayarlkhagva, Woon Kee Paek, Seong-Jin Kim, Stephen J. O'Brien, Jun Wang, Jong Bhak

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

225 Citations (Scopus)

85 Downloads (CityUHK Scholars)

Abstract

Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. © 2013 Macmillan Publishers Limited. All rights reserved.

Original language	English
Article number	2433
Journal	Nature Communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3433
Publication status	Published - 2013
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 15 Life on Land

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This full text is made available under CC-BY-NC-SA 3.0. https://creativecommons.org/licenses/by-nc-sa/3.0/

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10.1038/ncomms3433Licence: CC BY-NC-SA

96416140Final Published version, 881 KBLicence: CC BY-NC-SA

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Cho, Y. S., Hu, L., Hou, H., Lee, H., Xu, J., Kwon, S., Oh, S., Kim, H.-M., Jho, S., Kim, S., Shin, Y.-A., Kim, B. C., Kim, H., Kim, C.-U., Luo, S.-J., Johnson, W. E., Koepfli, K.-P., Schmidt-Küntzel, A., Turner, J. A., ... Bhak, J. (2013). The tiger genome and comparative analysis with lion and snow leopard genomes. Nature Communications, 4, Article 2433. https://doi.org/10.1038/ncomms3433

@article{c5987d2cd37d4ad0a03e1a8ac2cb7a9a,

title = "The tiger genome and comparative analysis with lion and snow leopard genomes",

abstract = "Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. {\textcopyright} 2013 Macmillan Publishers Limited. All rights reserved.",

author = "Cho, \{Yun Sung\} and Li Hu and Haolong Hou and Hang Lee and Jiaohui Xu and Soowhan Kwon and Sukhun Oh and Hak-Min Kim and Sungwoong Jho and Sangsoo Kim and Young-Ah Shin and Kim, \{Byung Chul\} and Hyunmin Kim and Chang-Uk Kim and Shu-Jin Luo and Johnson, \{Warren E.\} and Klaus-Peter Koepfli and Anne Schmidt-K{\"u}ntzel and Turner, \{Jason A.\} and Laurie Marker and Cindy Harper and Miller, \{Susan M.\} and Wilhelm Jacobs and Bertola, \{Laura D.\} and Kim, \{Tae Hyung\} and Sunghoon Lee and Qian Zhou and Hyun-Ju Jung and Xiao Xu and Priyvrat Gadhvi and Pengwei Xu and Yingqi Xiong and Yadan Luo and Shengkai Pan and Caiyun Gou and Xiuhui Chu and Jilin Zhang and Sanyang Liu and Jing He and Ying Chen and Linfeng Yang and Yulan Yang and Jiaju He and Sha Liu and Junyi Wang and Kim, \{Chul Hong\} and Hwanjong Kwak and Jong-Soo Kim and Seungwoo Hwang and Junsu Ko and Chang-Bae Kim and Sangtae Kim and Damdin Bayarlkhagva and Paek, \{Woon Kee\} and Seong-Jin Kim and O'Brien, \{Stephen J.\} and Jun Wang and Jong Bhak",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2013",

doi = "10.1038/ncomms3433",

language = "English",

volume = "4",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Springer Nature",

}

Cho, YS, Hu, L, Hou, H, Lee, H, Xu, J, Kwon, S, Oh, S, Kim, H-M, Jho, S, Kim, S, Shin, Y-A, Kim, BC, Kim, H, Kim, C-U, Luo, S-J, Johnson, WE, Koepfli, K-P, Schmidt-Küntzel, A, Turner, JA, Marker, L, Harper, C, Miller, SM, Jacobs, W, Bertola, LD, Kim, TH, Lee, S, Zhou, Q, Jung, H-J, Xu, X, Gadhvi, P, Xu, P, Xiong, Y, Luo, Y, Pan, S, Gou, C, Chu, X, Zhang, J, Liu, S, He, J, Chen, Y, Yang, L, Yang, Y, He, J, Liu, S, Wang, J, Kim, CH, Kwak, H, Kim, J-S, Hwang, S, Ko, J, Kim, C-B, Kim, S, Bayarlkhagva, D, Paek, WK, Kim, S-J, O'Brien, SJ, Wang, J & Bhak, J 2013, 'The tiger genome and comparative analysis with lion and snow leopard genomes', Nature Communications, vol. 4, 2433. https://doi.org/10.1038/ncomms3433

TY - JOUR

T1 - The tiger genome and comparative analysis with lion and snow leopard genomes

AU - Cho, Yun Sung

AU - Hu, Li

AU - Hou, Haolong

AU - Lee, Hang

AU - Xu, Jiaohui

AU - Kwon, Soowhan

AU - Oh, Sukhun

AU - Kim, Hak-Min

AU - Jho, Sungwoong

AU - Kim, Sangsoo

AU - Shin, Young-Ah

AU - Kim, Byung Chul

AU - Kim, Hyunmin

AU - Kim, Chang-Uk

AU - Luo, Shu-Jin

AU - Johnson, Warren E.

AU - Koepfli, Klaus-Peter

AU - Schmidt-Küntzel, Anne

AU - Turner, Jason A.

AU - Marker, Laurie

AU - Harper, Cindy

AU - Miller, Susan M.

AU - Jacobs, Wilhelm

AU - Bertola, Laura D.

AU - Kim, Tae Hyung

AU - Lee, Sunghoon

AU - Zhou, Qian

AU - Jung, Hyun-Ju

AU - Xu, Xiao

AU - Gadhvi, Priyvrat

AU - Xu, Pengwei

AU - Xiong, Yingqi

AU - Luo, Yadan

AU - Pan, Shengkai

AU - Gou, Caiyun

AU - Chu, Xiuhui

AU - Zhang, Jilin

AU - Liu, Sanyang

AU - He, Jing

AU - Chen, Ying

AU - Yang, Linfeng

AU - Yang, Yulan

AU - He, Jiaju

AU - Liu, Sha

AU - Wang, Junyi

AU - Kim, Chul Hong

AU - Kwak, Hwanjong

AU - Kim, Jong-Soo

AU - Hwang, Seungwoo

AU - Ko, Junsu

AU - Kim, Chang-Bae

AU - Kim, Sangtae

AU - Bayarlkhagva, Damdin

AU - Paek, Woon Kee

AU - Kim, Seong-Jin

AU - O'Brien, Stephen J.

AU - Wang, Jun

AU - Bhak, Jong

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2013

Y1 - 2013

N2 - Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. © 2013 Macmillan Publishers Limited. All rights reserved.

AB - Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. © 2013 Macmillan Publishers Limited. All rights reserved.

UR - https://www.scopus.com/pages/publications/84892877574

UR - https://www.scopus.com/pages/publications/84892877574#tab=impact

UR - https://app-overton-io.ezproxy.cityu.edu.hk/articles.php?query=10.1038/ncomms3433

U2 - 10.1038/ncomms3433

DO - 10.1038/ncomms3433

M3 - RGC 21 - Publication in refereed journal

C2 - 24045858

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

M1 - 2433

ER -

The tiger genome and comparative analysis with lion and snow leopard genomes

Abstract

Bibliographical note

UN SDGs

Publisher's Copyright Statement

Policy Impact

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