The Role of Single-Cell Technology in the Study and Control of Infectious Diseases

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

1 Scopus Citations
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Author(s)

  • Weikang Nicholas Lin
  • Matthew Zirui Tay
  • Ri Lu
  • Yi Liu
  • Lih Feng Cheow

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number1440
Number of pages28
Journal / PublicationCells
Volume9
Issue number6
Online published10 Jun 2020
Publication statusPublished - Jun 2020

Link(s)

Abstract

The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.

Research Area(s)

  • diagnostics, infectious disease, pathophysiology, single cell, therapeutics

Citation Format(s)

The Role of Single-Cell Technology in the Study and Control of Infectious Diseases. / Lin, Weikang Nicholas; Tay, Matthew Zirui; Lu, Ri; Liu, Yi; Chen, Chia-Hung; Cheow, Lih Feng.

In: Cells, Vol. 9, No. 6, 1440, 06.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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