The Role of Single-Cell Technology in the Study and Control of Infectious Diseases

Weikang Nicholas Lin; Matthew Zirui Tay; Ri Lu; Yi Liu; Chia-Hung Chen; Lih Feng Cheow

doi:10.3390/cells9061440

The Role of Single-Cell Technology in the Study and Control of Infectious Diseases

Weikang Nicholas Lin, Matthew Zirui Tay, Ri Lu, Yi Liu, Chia-Hung Chen, Lih Feng Cheow^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

21 Citations (Scopus)

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Abstract

The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.

Original language	English
Article number	1440
Number of pages	28
Journal	Cells
Volume	9
Issue number	6
Online published	10 Jun 2020
DOIs	https://doi.org/10.3390/cells9061440
Publication status	Published - Jun 2020

Research Keywords

diagnostics
infectious disease
pathophysiology
single cell
therapeutics

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.",

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AU - Lu, Ri

AU - Liu, Yi

AU - Chen, Chia-Hung

AU - Cheow, Lih Feng

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Y1 - 2020/6

N2 - The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.

AB - The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.

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KW - infectious disease

KW - pathophysiology

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KW - therapeutics

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KW - therapeutics

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KW - infectious disease

KW - pathophysiology

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The Role of Single-Cell Technology in the Study and Control of Infectious Diseases

Abstract

Research Keywords

Publisher's Copyright Statement

UN SDGs

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