The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy

Angela Kwok-Fung Lo; Christopher W. Dawson; Hong Lok Lung; Ka-Leung Wong; Lawrence S. Young

doi:10.3389/fonc.2021.640207

The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy

Angela Kwok-Fung Lo, Christopher W. Dawson, Hong Lok Lung, Ka-Leung Wong^*, Lawrence S. Young^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

84 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies. © 2021 Lo, Dawson, Lung, Wong and Young.

Original language	English
Article number	640207
Number of pages	17
Journal	Frontiers in Oncology
Volume	11
Online published	25 Feb 2021
DOIs	https://doi.org/10.3389/fonc.2021.640207
Publication status	Published - Feb 2021
Externally published	Yes

Funding

This work was supported by Research Grants Council of Hong Kong (Grant No. HKBU12300117).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Epstein-Barr virus
latent membrane protein 1
nasopharyngeal carcinoma
therapy
tumor microenvironment

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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abstract = "Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies. {\textcopyright} 2021 Lo, Dawson, Lung, Wong and Young.",

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T2 - From Function to Therapy

AU - Lo, Angela Kwok-Fung

AU - Dawson, Christopher W.

AU - Lung, Hong Lok

AU - Wong, Ka-Leung

AU - Young, Lawrence S.

PY - 2021/2

Y1 - 2021/2

N2 - Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies. © 2021 Lo, Dawson, Lung, Wong and Young.

AB - Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies. © 2021 Lo, Dawson, Lung, Wong and Young.

KW - Epstein-Barr virus

KW - latent membrane protein 1

KW - nasopharyngeal carcinoma

KW - therapy

KW - tumor microenvironment

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DO - 10.3389/fonc.2021.640207

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M1 - 640207

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The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy

Abstract

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Research Keywords

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