The role of autophagy in iNKT cell development
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Article number | 2653 |
| Number of pages | 7 |
| Journal / Publication | Frontiers in Immunology |
| Volume | 9 |
| Online published | 14 Nov 2018 |
| Publication status | Published - Nov 2018 |
| Externally published | Yes |
Link(s)
| DOI | DOI |
|---|---|
| Attachment(s) | Documents
Publisher's Copyright Statement
|
| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85056645788&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(01b3f670-ac2b-4650-98b1-92f8aef76fef).html |
Abstract
CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and function of iNKT cells are regulated by many different cellular processes, including autophagy, a self-degradation mechanism. In this mini review, we discuss the current understanding of how autophagy regulates iNKT cell development and effector lineage differentiation. Importantly, we propose that iNKT cell development is tightly controlled by metabolic reprogramming.
Research Area(s)
- invariant natural killer T cells, CD1d, autophagy, thymic development, metabolic switch
Citation Format(s)
The role of autophagy in iNKT cell development. / Yang, Guan; Driver, John P.; Van Kaer, Luc.
In: Frontiers in Immunology, Vol. 9, 2653, 11.2018.
In: Frontiers in Immunology, Vol. 9, 2653, 11.2018.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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