The role of AQP4 in neuromyelitis optica: More answers, more questions

Xin Yang; Bruce R. Ransom; Jian-Fang Ma

doi:10.1016/j.jneuroim.2016.06.002

The role of AQP4 in neuromyelitis optica: More answers, more questions

Xin Yang
, Bruce R. Ransom
, Jian-Fang Ma^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

34 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the central nervous system (CNS), is a reliable biomarker for NMO. These antibodies, NMO-IgG, may be responsible for the sequential cascade of immune events, including IgG/IgM deposition, infiltration of granulocytes and complement-mediated cytotoxicity (i.e. astrocyte loss) and demyelination. This review summarizes current thinking about the role of NMO-IgG in the pathogenesis of this condition. New insights were also generated along with important additional questions.

Original language	English
Pages (from-to)	63-70
Journal	Journal of Neuroimmunology
Volume	298
Online published	7 Jun 2016
DOIs	https://doi.org/10.1016/j.jneuroim.2016.06.002
Publication status	Published - 15 Sept 2016
Externally published	Yes

Research Keywords

Complement
Demyelination
Glutamate
Neuromyelitis optica
Potassium channel
Water channel protein aquaporin-4

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@article{78ac86c519c8464587b3dcd4ecbe6ce8,

title = "The role of AQP4 in neuromyelitis optica: More answers, more questions",

abstract = "Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the central nervous system (CNS), is a reliable biomarker for NMO. These antibodies, NMO-IgG, may be responsible for the sequential cascade of immune events, including IgG/IgM deposition, infiltration of granulocytes and complement-mediated cytotoxicity (i.e. astrocyte loss) and demyelination. This review summarizes current thinking about the role of NMO-IgG in the pathogenesis of this condition. New insights were also generated along with important additional questions.",

keywords = "Complement, Demyelination, Glutamate, Neuromyelitis optica, Potassium channel, Water channel protein aquaporin-4",

author = "Xin Yang and Ransom, \{Bruce R.\} and Jian-Fang Ma",

year = "2016",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2016.06.002",

language = "English",

volume = "298",

pages = "63--70",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - The role of AQP4 in neuromyelitis optica

T2 - More answers, more questions

AU - Yang, Xin

AU - Ransom, Bruce R.

AU - Ma, Jian-Fang

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the central nervous system (CNS), is a reliable biomarker for NMO. These antibodies, NMO-IgG, may be responsible for the sequential cascade of immune events, including IgG/IgM deposition, infiltration of granulocytes and complement-mediated cytotoxicity (i.e. astrocyte loss) and demyelination. This review summarizes current thinking about the role of NMO-IgG in the pathogenesis of this condition. New insights were also generated along with important additional questions.

AB - Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the central nervous system (CNS), is a reliable biomarker for NMO. These antibodies, NMO-IgG, may be responsible for the sequential cascade of immune events, including IgG/IgM deposition, infiltration of granulocytes and complement-mediated cytotoxicity (i.e. astrocyte loss) and demyelination. This review summarizes current thinking about the role of NMO-IgG in the pathogenesis of this condition. New insights were also generated along with important additional questions.

KW - Complement

KW - Demyelination

KW - Glutamate

KW - Neuromyelitis optica

KW - Potassium channel

KW - Water channel protein aquaporin-4

UR - https://www.scopus.com/pages/publications/84978289156

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84978289156&origin=recordpage

U2 - 10.1016/j.jneuroim.2016.06.002

DO - 10.1016/j.jneuroim.2016.06.002

M3 - RGC 21 - Publication in refereed journal

C2 - 27609277

SN - 0165-5728

VL - 298

SP - 63

EP - 70

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

The role of AQP4 in neuromyelitis optica: More answers, more questions

Abstract

Research Keywords

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