The role of AQP4 in neuromyelitis optica: More answers, more questions

Xin Yang; Bruce R. Ransom; Jian-Fang Ma

doi:10.1016/j.jneuroim.2016.06.002

Author(s)

Xin Yang
Bruce R. Ransom
Jian-Fang Ma

Detail(s)

Original language	English
Pages (from-to)	63-70
Journal / Publication	Journal of Neuroimmunology
Volume	298
Online published	7 Jun 2016
Publication status	Published - 15 Sept 2016
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.jneuroim.2016.06.002 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84978289156&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(78ac86c5-19c8-4645-87b3-dcd4ecbe6ce8).html

Abstract

Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the central nervous system (CNS), is a reliable biomarker for NMO. These antibodies, NMO-IgG, may be responsible for the sequential cascade of immune events, including IgG/IgM deposition, infiltration of granulocytes and complement-mediated cytotoxicity (i.e. astrocyte loss) and demyelination. This review summarizes current thinking about the role of NMO-IgG in the pathogenesis of this condition. New insights were also generated along with important additional questions.

Research Area(s)

Complement, Demyelination, Glutamate, Neuromyelitis optica, Potassium channel, Water channel protein aquaporin-4

Citation Format(s)

[ RIS ] [ BibTeX ]

The role of AQP4 in neuromyelitis optica: More answers, more questions. / Yang, Xin; Ransom, Bruce R.; Ma, Jian-Fang.
In: Journal of Neuroimmunology, Vol. 298, 15.09.2016, p. 63-70.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Yang, X, Ransom, BR & Ma, J-F 2016, 'The role of AQP4 in neuromyelitis optica: More answers, more questions', Journal of Neuroimmunology, vol. 298, pp. 63-70. https://doi.org/10.1016/j.jneuroim.2016.06.002

Yang, X., Ransom, B. R., & Ma, J.-F. (2016). The role of AQP4 in neuromyelitis optica: More answers, more questions. Journal of Neuroimmunology, 298, 63-70. https://doi.org/10.1016/j.jneuroim.2016.06.002

Yang X, Ransom BR, Ma JF. The role of AQP4 in neuromyelitis optica: More answers, more questions. Journal of Neuroimmunology. 2016 Sept 15;298:63-70. Epub 2016 Jun 7. doi: 10.1016/j.jneuroim.2016.06.002

Yang, Xin ; Ransom, Bruce R. ; Ma, Jian-Fang. / The role of AQP4 in neuromyelitis optica : More answers, more questions. In: Journal of Neuroimmunology. 2016 ; Vol. 298. pp. 63-70.

The role of AQP4 in neuromyelitis optica : More answers, more questions