The rational design of a peptide-based hydrogel responsive to H2S

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

25 Scopus Citations
View graph of relations

Author(s)

  • Raoul Peltier
  • Ganchao Chen
  • Haipeng Lei
  • Mei Zhang
  • Liqian Gao
  • Su Seong Lee

Detail(s)

Original languageEnglish
Pages (from-to)17273-17276
Journal / PublicationChemical Communications
Volume51
Issue number97
Online published2 Oct 2015
Publication statusPublished - 18 Dec 2015

Abstract

The development of hydrogels that are responsive to external stimuli in a well-controlled manner is important for numerous biomedical applications. Herein we reported the first example of a hydrogel responsive to hydrogen sulphide (H2S). H2S is an important gasotransmitter whose deregulation has been associated with a number of pathological conditions. Our hydrogel design is based on the functionalization of an ultrashort hydrogelating peptide sequence with an azidobenzyl moiety, which was reported to react with H2S selectively under physiological conditions. The resulting peptide was able to produce hydrogels at a concentration as low as 0.1 wt%. It could then be fully degraded in the presence of excess H2S. We envision that the novel hydrogel developed in this study may provide useful tools for biomedical research.

Citation Format(s)

The rational design of a peptide-based hydrogel responsive to H2S. / Peltier, Raoul; Chen, Ganchao; Lei, Haipeng; Zhang, Mei; Gao, Liqian; Lee, Su Seong; Wang, Zuankai; Sun, Hongyan.

In: Chemical Communications, Vol. 51, No. 97, 18.12.2015, p. 17273-17276.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal