The plate-to-rod transition in trabecular bone loss is elusive

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • A. A. Felder
  • S. Monzem
  • R. De Souza
  • B. Javaheri
  • D. Mills
  • A. Boyde

Detail(s)

Original languageEnglish
Article number201401
Journal / PublicationRoyal Society Open Science
Volume8
Issue number6
Online published9 Jun 2021
Publication statusPublished - Jun 2021

Link(s)

Abstract

Changes in trabecular micro-architecture are key to our understanding of osteoporosis. Previous work focusing on structure model index (SMI) measurements have concluded that disease progression entails a shift from plates to rods in trabecular bone, but SMI is heavily biased by bone volume fraction. As an alternative to SMI, we proposed the ellipsoid factor (EF) as a continuous measure of local trabecular shape between plate-like and rod-like extremes. We investigated the relationship between EF distributions, SMI and bone volume fraction of the trabecular geometry in a murine model of disuse osteoporosis as well as from human vertebrae of differing bone volume fraction. We observed a moderate shift in EF median (at later disease stages in mouse tibia) and EF mode (in the vertebral samples with low bone volume fraction) towards a more rod-like geometry, but not in EF maximum and minimum. These results support the notion that the plate to rod transition does not coincide with the onset of bone loss and is considerably more moderate, when it does occur, than SMI suggests. A variety of local shapes not straightforward to categorize as rod or plate exist in all our trabecular bone samples. 

Research Area(s)

  • ellipsoid factor, structure model index, plates, rods, trabecular bone, osteoporosis

Bibliographic Note

Research Unit(s) information for this publication is provided by the author(s) concerned.

Citation Format(s)

The plate-to-rod transition in trabecular bone loss is elusive. / Felder, A. A.; Monzem, S.; De Souza, R.; Javaheri, B.; Mills, D.; Boyde, A.; Doube, M.

In: Royal Society Open Science, Vol. 8, No. 6, 201401, 06.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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