The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

22 Scopus Citations
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Author(s)

  • Fei-Fei An
  • Jia-Xiong Chen
  • Jia Yu
  • Wen-Wen Tao
  • Zhiqiang Yu
  • Richard Ting
  • Xiao-Hong Zhang

Detail(s)

Original languageEnglish
Article number1903121
Journal / PublicationSmall
Volume15
Issue number38
Online published5 Aug 2019
Publication statusPublished - 18 Sep 2019

Abstract

The combination of diagnostic and therapeutic functions in a single theranostic nanoagent generally requires the integration of multi-ingredients. Herein, a cytotoxic near-infrared (NIR) dye (IR-797) and its nanoassembly are reported for multifunctional cancer theranostics. The hydrophobic IR-797 molecules are self-assembled into nanoparticles, which are further modified with an amphiphilic polymer (C18PMH-PEG5000) on the surface. The prepared PEG-IR-797 nanoparticles (PEG-IR-797 NPs) possess inherent cytotoxicity from the IR-797 dye and work as a chemotherapeutic drug which induces apoptosis of cancer cells. The IR-797 NPs are found to have an ultrahigh mass extinction coefficient (444.3 L g−1 cm−1 at 797 nm and 385.9 L g−1 cm−1 at 808 nm) beyond all reported organic nanomaterials (<40 L g−1 cm−1) for superior photothermal therapy (PTT). In addition, IR-797 shows some aggregation-induced-emission (AIE) properties. Combining the merits of good NIR absorption, high photothermal energy conversion efficiency, and AIE, makes the PEG-IR-797 NPs useful for multimodal NIR AIE fluorescence, photoacoustic, and thermal imaging-guided therapy. The research exhibits the possibility of using a single ingredient and entity to perform multimodal NIR fluorescence, photoacoustic, and thermal imaging-guided chemo-/photothermal combination therapy, which may trigger wide interest from the fields of nanomedicine and medicinal chemistry to explore multifunctional theranostic organic molecules.

Research Area(s)

  • combination therapy, photoacoustic imaging, photothermal therapy, theranostics, ultrahigh mass extinction coefficient

Citation Format(s)

The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics. / Xiao, Ya-Fang; An, Fei-Fei; Chen, Jia-Xiong; Yu, Jia; Tao, Wen-Wen; Yu, Zhiqiang; Ting, Richard; Lee, Chun-Sing; Zhang, Xiao-Hong.

In: Small, Vol. 15, No. 38, 1903121, 18.09.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal