The moose, purine degradation, and environmental adaptation

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)937-939
Journal / PublicationEuropean Journal of Wildlife Research
Volume60
Issue number6
Publication statusPublished - 6 Nov 2014
Externally publishedYes

Abstract

It is accepted that allantoin is the end-product of purine degradation in mammals, except that uricase activity has been lost during the evolution of humans in which uric acid protects the brain from oxidative damage. However, we have found that the moose Alces americanus excretes extremely low urinary concentrations of allantoin and high concentrations of uric acid very similar to those of humans. Exposure to extreme cold is known to cause oxidative damage, and we suggest that the retention of uric acid by the moose represents an adaptation enabling the species to survive at high latitudes.

Research Area(s)

  • Alces americanus, China, Purine degradation, Uric acid

Citation Format(s)

The moose, purine degradation, and environmental adaptation. / Zhang, Weiqi; Stott, Philip; Zhang, Minghai.
In: European Journal of Wildlife Research, Vol. 60, No. 6, 06.11.2014, p. 937-939.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review