The molecularly imprinted polymer essentials : curation of anticancer, ophthalmic, and projected gene therapy drug delivery systems

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)62_Review of books or of software (or similar publications/items)peer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)24-34
Journal / PublicationJournal of Controlled Release
Volume287
Online published12 Aug 2018
Publication statusPublished - 10 Oct 2018

Abstract

The development of polymeric materials as drug delivery systems has advanced from systems that rely on classical passive targeting to carriers that can sustain the precisely controlled release of payloads upon physicochemical triggers in desired microenvironment. Molecularly imprinted polymers (MIP), materials designed to capture specific molecules based on their molecular shape and charge distribution, are attractive candidates for fulfilling these purposes. In particular, drug-imprinted polymers coupled with active targeting mechanisms have been explored as potential drug delivery systems. In this review, we have curated important recent efforts in the development of drug-imprinted polymers in a variety of clinical applications, especially oncology and ophthalmology. MIP possesses properties that may complement the traditional delivery systems of these two disciplines, such as passive enhanced permeability and retention effect (EPR) in cancer tumors, and passive drug diffusion in delivering ophthalmic therapeutics. Furthermore, the prospects of MIP integration with the emerging gene therapies will be discussed.

Research Area(s)

  • Cancer, Drug delivery, Gene therapy, Imprinting, Ophthalmic, Sustained release

Citation Format(s)

The molecularly imprinted polymer essentials : curation of anticancer, ophthalmic, and projected gene therapy drug delivery systems. / Tuwahatu, Christian Antonio; Yeung, Chi Chung; Lam, Yun Wah; Roy, Vellaisamy Arul Lenus.

In: Journal of Controlled Release, Vol. 287, 10.10.2018, p. 24-34.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)62_Review of books or of software (or similar publications/items)peer-review