The Modulation of Stem Cell Behaviors by Functionalized Nanoceramic Coatings on Ti-Based Implants

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

19 Scopus Citations
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Author(s)

  • Xiangmei Liu
  • Man Li
  • Yizhou Zhu
  • K.W.K Yeung
  • Shuilin Wu

Detail(s)

Original languageEnglish
Pages (from-to)65-76
Journal / PublicationBioactive Materials
Volume1
Issue number1
Online published13 Sep 2016
Publication statusPublished - Sep 2016

Link(s)

Abstract

Nanoceramic coating on the surface of Ti-based metallic implants is a clinical potential option in orthopedic surgery. Stem cells have been found to have osteogenic capabilities. It is necessary to study the influences of functionalized nanoceramic coatings on the differentiation and proliferation of stem cells in vitro or in vivo. In this paper, we summarized the recent advance on the modulation of stem cells behaviors through controlling the properties of nanoceramic coatings, including surface chemistry, surface roughness and microporosity. In addition, mechanotransduction pathways have also been discussed to reveal the interaction mechanisms between the stem cells and ceramic coatings on Ti-based metals. In the final part, the osteoinduction and osteoconduction of ceramic coating have been also presented when it was used as carrier of BMPs in new bone formation.

Research Area(s)

  • Implants, Modulation, Nanoceramic coating, Stem cell, Ti

Citation Format(s)

The Modulation of Stem Cell Behaviors by Functionalized Nanoceramic Coatings on Ti-Based Implants. / Liu, Xiangmei; Li, Man; Zhu, Yizhou; Yeung, K.W.K; Chu, Paul K.; Wu, Shuilin.

In: Bioactive Materials, Vol. 1, No. 1, 09.2016, p. 65-76.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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