The marine medaka Oryzias melastigma - A potential marine fish model for innate immune study
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 267-276 |
| Journal / Publication | Marine Pollution Bulletin |
| Volume | 63 |
| Issue number | 5-12 |
| Publication status | Published - 2011 |
Link(s)
Abstract
The objective of this study is to develop the marine medaka Oryzias melastigma as a potential marine fish model for innate immune and immunotoxicological studies. Hepcidin plays an important role in innate immune system. Two hepcidin genes (OM-hep1 and OM-hep2) were identified and characterized in the O. melastigma, which were highly conserved with other reported hepcidins. During embryogenesis, significant elevation of OM-hep1 and OM-hep2 transcripts were coincided with liver development in the embryos. In adult medaka, differential tissue expressions of both hepcidin transcripts were evident: high in liver, moderate in spleen and low in non-immune tissues. After bacterial challenge, the two hepcidin mRNAs were rapidly and remarkably induced in liver and spleen, suggesting the two OM-hepcidins in O. melastigma play a complementary role in innate defense. Gender difference in time of induction and extent of the two hepcidin mRNAs elevation in infected O. melastigma should be considered in immunotoxicological studies. © 2011 Elsevier Ltd.
Research Area(s)
- Bacterial challenge, Hepcidin, Immunotoxicology, Innate immune response, Marine medaka
Citation Format(s)
The marine medaka Oryzias melastigma - A potential marine fish model for innate immune study. / Bo, Jun; Cai, Ling; Xu, Jia-He et al.
In: Marine Pollution Bulletin, Vol. 63, No. 5-12, 2011, p. 267-276.
In: Marine Pollution Bulletin, Vol. 63, No. 5-12, 2011, p. 267-276.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
