The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis

Ruixuan HUANG; William C. CHO; Yanni SUN; Kei Hang Katie CHAN

doi:10.1109/embc44109.2020.9176344

The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis

Ruixuan HUANG, William C. CHO, Yanni SUN, Kei Hang Katie CHAN

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

4 Citations (Scopus)

35 Downloads (CityUHK Scholars)

Abstract

Lung cancer is a major public health burden and among the highest incidence and mortality rates of the cancers. MicroRNAs (miRNAs) play an important role in the development of lung cancer. The aim of this study was to investigate whether there was a potential causal relation between miRNAs and non-small-cell lung cancer (NSCLC). 1,026patients with NSCLC from The Cancer Genome Atlas (TCGA)were analyzed. NSCLC associated SNPs' allele scores were established, and candidate miRNAs were filtered from differential expression analysis. Mendelian randomization (MR)analysis was conducted for 5 candidate miRNA (hsa-miR-135b,hsa-miR-142, hsa-miR-182, hsa-miR-183 and hsa-miR-3607)and 76 candidate SNPs in lung adenocarcinoma (LUAD) group. According to the core assumptions of MR, there was no clear evidence of a causal relation between the 5 candidate miRNAs and LUAD. The reads per million miRNAs mapped (RPM) level of candidate miRNAs changed less than 3% per allele score. To our knowledge, this is the first study using the TCGA data set to investigate the causal relation between miRNAs and lung cancer using the MR approach, and also one of the first MR studies to use miRNA expression as an exposure factor, with the SNPs as instrumental variables.

Original language	English
Title of host publication	2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Publisher	IEEE
Pages	2346-2352
ISBN (Electronic)	9781728119908
ISBN (Print)	9781728119915
DOIs	https://doi.org/10.1109/embc44109.2020.9176344
Publication status	Published - Jul 2020
Event	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020): "Enabling Innovative Technologies for Global Healthcare” - Virtual Conference, Montreal, Canada Duration: 20 Jul 2020 → 24 Jul 2020

Publication series

Name	IEEE Engineering in Medicine and Biology Society Conference Proceedings
ISSN (Print)	2375-7477
ISSN (Electronic)	2694-0604

Conference

Conference	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020)
Abbreviated title	EMBC'20
Country/Territory	Canada
City	Montreal
Period	20/07/20 → 24/07/20

Bibliographical note

Research Unit(s) information for this publication is provided by the author(s) concerned.

Research Keywords

ADENOCARCINOMA
INFLAMMATION
SIMILARITY
DATABASE
MIRNAS

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/embc44109.2020.9176344

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HUANG, R., CHO, W. C., SUN, Y., & CHAN, K. H. K. (2020). The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 2346-2352). (IEEE Engineering in Medicine and Biology Society Conference Proceedings). IEEE. https://doi.org/10.1109/embc44109.2020.9176344

HUANG, Ruixuan ; CHO, William C. ; SUN, Yanni et al. / The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms : a Mendelian Randomization Analysis. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2020. pp. 2346-2352 (IEEE Engineering in Medicine and Biology Society Conference Proceedings).

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title = "The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis",

abstract = "Lung cancer is a major public health burden and among the highest incidence and mortality rates of the cancers. MicroRNAs (miRNAs) play an important role in the development of lung cancer. The aim of this study was to investigate whether there was a potential causal relation between miRNAs and non-small-cell lung cancer (NSCLC). 1,026patients with NSCLC from The Cancer Genome Atlas (TCGA)were analyzed. NSCLC associated SNPs' allele scores were established, and candidate miRNAs were filtered from differential expression analysis. Mendelian randomization (MR)analysis was conducted for 5 candidate miRNA (hsa-miR-135b,hsa-miR-142, hsa-miR-182, hsa-miR-183 and hsa-miR-3607)and 76 candidate SNPs in lung adenocarcinoma (LUAD) group. According to the core assumptions of MR, there was no clear evidence of a causal relation between the 5 candidate miRNAs and LUAD. The reads per million miRNAs mapped (RPM) level of candidate miRNAs changed less than 3% per allele score. To our knowledge, this is the first study using the TCGA data set to investigate the causal relation between miRNAs and lung cancer using the MR approach, and also one of the first MR studies to use miRNA expression as an exposure factor, with the SNPs as instrumental variables.",

keywords = "ADENOCARCINOMA, INFLAMMATION, SIMILARITY, DATABASE, MIRNAS",

author = "Ruixuan HUANG and CHO, {William C.} and Yanni SUN and CHAN, {Kei Hang Katie}",

note = "Research Unit(s) information for this publication is provided by the author(s) concerned.; 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020) : {"}Enabling Innovative Technologies for Global Healthcare”, EMBC'20 ; Conference date: 20-07-2020 Through 24-07-2020",

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language = "English",

isbn = "9781728119915",

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HUANG, R, CHO, WC, SUN, Y & CHAN, KHK 2020, The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis. in 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE Engineering in Medicine and Biology Society Conference Proceedings, IEEE, pp. 2346-2352, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020), Montreal, Quebec, Canada, 20/07/20. https://doi.org/10.1109/embc44109.2020.9176344

The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis. / HUANG, Ruixuan; CHO, William C.; SUN, Yanni et al.
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2020. p. 2346-2352 (IEEE Engineering in Medicine and Biology Society Conference Proceedings).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms

T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC 2020)

AU - HUANG, Ruixuan

AU - CHO, William C.

AU - SUN, Yanni

AU - CHAN, Kei Hang Katie

N1 - Research Unit(s) information for this publication is provided by the author(s) concerned.

PY - 2020/7

Y1 - 2020/7

N2 - Lung cancer is a major public health burden and among the highest incidence and mortality rates of the cancers. MicroRNAs (miRNAs) play an important role in the development of lung cancer. The aim of this study was to investigate whether there was a potential causal relation between miRNAs and non-small-cell lung cancer (NSCLC). 1,026patients with NSCLC from The Cancer Genome Atlas (TCGA)were analyzed. NSCLC associated SNPs' allele scores were established, and candidate miRNAs were filtered from differential expression analysis. Mendelian randomization (MR)analysis was conducted for 5 candidate miRNA (hsa-miR-135b,hsa-miR-142, hsa-miR-182, hsa-miR-183 and hsa-miR-3607)and 76 candidate SNPs in lung adenocarcinoma (LUAD) group. According to the core assumptions of MR, there was no clear evidence of a causal relation between the 5 candidate miRNAs and LUAD. The reads per million miRNAs mapped (RPM) level of candidate miRNAs changed less than 3% per allele score. To our knowledge, this is the first study using the TCGA data set to investigate the causal relation between miRNAs and lung cancer using the MR approach, and also one of the first MR studies to use miRNA expression as an exposure factor, with the SNPs as instrumental variables.

AB - Lung cancer is a major public health burden and among the highest incidence and mortality rates of the cancers. MicroRNAs (miRNAs) play an important role in the development of lung cancer. The aim of this study was to investigate whether there was a potential causal relation between miRNAs and non-small-cell lung cancer (NSCLC). 1,026patients with NSCLC from The Cancer Genome Atlas (TCGA)were analyzed. NSCLC associated SNPs' allele scores were established, and candidate miRNAs were filtered from differential expression analysis. Mendelian randomization (MR)analysis was conducted for 5 candidate miRNA (hsa-miR-135b,hsa-miR-142, hsa-miR-182, hsa-miR-183 and hsa-miR-3607)and 76 candidate SNPs in lung adenocarcinoma (LUAD) group. According to the core assumptions of MR, there was no clear evidence of a causal relation between the 5 candidate miRNAs and LUAD. The reads per million miRNAs mapped (RPM) level of candidate miRNAs changed less than 3% per allele score. To our knowledge, this is the first study using the TCGA data set to investigate the causal relation between miRNAs and lung cancer using the MR approach, and also one of the first MR studies to use miRNA expression as an exposure factor, with the SNPs as instrumental variables.

KW - ADENOCARCINOMA

KW - INFLAMMATION

KW - SIMILARITY

KW - DATABASE

KW - MIRNAS

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U2 - 10.1109/embc44109.2020.9176344

DO - 10.1109/embc44109.2020.9176344

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781728119915

T3 - IEEE Engineering in Medicine and Biology Society Conference Proceedings

SP - 2346

EP - 2352

BT - 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

PB - IEEE

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ER -

HUANG R, CHO WC, SUN Y , CHAN KHK. The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE. 2020. p. 2346-2352. (IEEE Engineering in Medicine and Biology Society Conference Proceedings). doi: 10.1109/embc44109.2020.9176344

The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis

Abstract

Publication series

Conference

Bibliographical note

Research Keywords

Publisher's Copyright Statement

UN SDGs

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Complex Disease Prediction, Prevention, and Treatment Using Computational Methods

Cite this

The Lung Cancer Associated MicroRNAs and Single Nucleotides Polymorphisms: a Mendelian Randomization Analysis

Abstract

Publication series

Conference

Bibliographical note

Research Keywords

Publisher's Copyright Statement

UN SDGs

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Student theses

Complex Disease Prediction, Prevention, and Treatment Using Computational Methods

Cite this