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The Impact of Diabetes Mellitus on the Osseointegration of Absorbable Screws: An Animal Experimental Investigation

  • Zelin WU (Co-first Author)
  • , Lei XIAO (Co-first Author)
  • , Huige HOU (Co-first Author)
  • , Ling LI
  • , Yanping GAO
  • , Jian GUAN
  • , Jiwen CHEN
  • , Lingfeng ZENG
  • , Zihang CHEN
  • , Tsz-Ngai MOK
  • , Guiqiang MIAO
  • , Xiaofei ZHENG*
  • , Shiguo YUAN
  • , Huajun WANG
    • *Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Abstract

This study aims to explore the correlation between alterations in blood glucose levels and the osseointegration as well as biomechanical properties of nHA/PLLA absorbable screws, and elucidate the impact of DM on bone metabolism surrounding nHA/PLLA absorbable screws. 75 rats were randomly assigned to either the Diabetes mellitus (DM) group and the control group. DM was induced in rats through intraperitoneal injection of 1% streptozotocin. A single nHA/PLLA absorbable screw was surgically implanted into the medial tibia of each rat in both groups. Rats were euthanized at 4 weeks, 8 weeks and 12 weeks post-implantation, and tissue specimens were subjected to histological, histomorphological, Micro-CT scan, biomechanical, microindentation mechanical testing of trabeculae bone, Raman spectroscopy, and Western blot analyses. Changes in bone mass, trabeculae structure, composition, mechanical properties, and expression of bone formation-related proteins around the absorbable screws were compared between the two groups at the microscopic, biomechanical, and molecular levels. The results show that DM disrupts the trabeculae structure surrounding absorbable screws, leading to alterations in trabeculae bone composition, diminished mechanical properties, and impaired bone metabolism. DM significantly compromises osseointegration at the absorbable screw-bone interface and diminishes bone quality in the vicinity of the absorbable screw. © 2025 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.
Original languageEnglish
Pages (from-to)827-838
JournalSains Malaysiana
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 2025

Bibliographical note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

Funding

This research was funded by Hainan Province Clinical Medical Center ([2021] No. 276), Scientific research and cultivation fund of the Affiliated Shunde Hospital of Jinan University (No.202101002), Medical Scientific Research Foundation of Guangdong Province (A2023143), the Fundamental Research Funds for the Central Universities (21623319), the Funding of Science and Technology Projects in Guangzhou (SL2023A04J01317), Medical Joint Fund of Jinan University (YXJC2022005). The study was conducted in accordance with the Declaration of Helsinki, and approved by the Jinan University Animal Ethics Committee (20180531-07). The original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding authors. Author contributions is as follows: ZW, LX, HH contributed equally. Conceptualization, ZW, LX, HH, LL, YG, JG, JC and LZ; methodology, ZW, LX, HH and ZC; software, ZW, LX and HH; validation, ZW, LX and HH; formal analysis, LL, YG, JG and JC.; investigation, LL, YG, JG and JC; resources, ZC; data curation, ZW and LX; writing - original draft preparation, ZW, LX and HH; writing - review and editing, XZ, SY and HW; visualization, ZW and ZC; supervision, GM and TM; project administration, XZ, SY and HW; funding acquisition, XZ, SY and HW. All authors have read and agreed to the published version of the manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Research Keywords

  • Absorbable screw
  • diabetes mellitus
  • nHA/PLLA
  • osseointegration

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