The genome variation and developmental transcriptome maps reveal genetic differentiation of skeletal muscle in pigs

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yalan Yang
  • Junyu Yan
  • Xinhao Fan
  • Xiaoqin Liu
  • Guoqiang Yi
  • Yuwen Liu
  • Yongchao Niu
  • Longchao Zhang
  • Lixian Wang
  • Kui Li
  • Zhonglin Tang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article numbere1009910
Journal / PublicationPLoS Genetics
Volume17
Issue number11
Online published15 Nov 2021
Publication statusPublished - Nov 2021

Link(s)

Abstract

Natural and artificial directional selections have resulted in significantly genetic and phenotypic differences across breeds in domestic animals. However, the molecular regulation of skeletal muscle diversity remains largely unknown. Here, we conducted transcriptome profiling of skeletal muscle across 27 time points, and performed whole-genome re-sequencing in Landrace (lean-type) and Tongcheng (obese-type) pigs. The transcription activity decreased with development, and the high-resolution transcriptome precisely captured the characterizations of skeletal muscle with distinct biological events in four developmental phases: Embryonic, Fetal, Neonatal, and Adult. A divergence in the developmental timing and asynchronous development between the two breeds was observed; Landrace showed a developmental lag and stronger abilities of myoblast proliferation and cell migration, whereas Tongcheng had higher ATP synthase activity in postnatal periods. The miR-24-3p driven network targeting insulin signaling pathway regulated glucose metabolism. Notably, integrated analysis suggested SATB2 and XLOC-036765 contributed to skeletal muscle diversity via regulating the myoblast migration and proliferation, respectively. Overall, our results provide insights into the molecular regulation of skeletal muscle development and diversity in mammals.

Research Area(s)

Citation Format(s)

The genome variation and developmental transcriptome maps reveal genetic differentiation of skeletal muscle in pigs. / Yang, Yalan; Yan, Junyu; Fan, Xinhao et al.
In: PLoS Genetics, Vol. 17, No. 11, e1009910, 11.2021.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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