Abstract
Biohybrid regenerative bioelectronics are an emerging technology combining implantable devices with cell transplantation. Once implanted, biohybrid regenerative devices integrate with host tissue. The combination of transplant and device provides an avenue to both replace damaged or dysfunctional tissue, and monitor or control its function with high precision. While early challenges in the fusion of the biological and technological components limited development of biohybrid regenerative technologies, progress in the field has resulted in a rapidly increasing number of applications. In this perspective the great potential of this emerging technology for the delivery of therapy is discussed, including both recent research progress and potential new directions. Then the technology barriers are discussed that will need to be addressed to unlock the full potential of biohybrid regenerative devices. © 2024 The Author(s). Advanced Materials published by Wiley-VCH GmbH.
| Original language | English |
|---|---|
| Article number | 2408308 |
| Number of pages | 9 |
| Journal | Advanced Materials |
| Volume | 37 |
| Issue number | 3 |
| Online published | 20 Nov 2024 |
| DOIs | |
| Publication status | Published - 22 Jan 2025 |
| Externally published | Yes |
Funding
A.C.L. acknowledges support from the University of Cambridge for a Borysiewicz Interdisciplinary Fellowship and the Wellcome Trust for a Junior Interdisciplinary Fellowship.
Research Keywords
- biohybrid interfaces
- cell transplantation
- implantable devices
- neural interfaces
- regenerative bioelectronics
Publisher's Copyright Statement
- This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
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