The first neurons of the human cerebral cortex

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)880-886
Journal / PublicationNature Neuroscience
Volume9
Issue number7
Online published18 Jun 2006
Publication statusPublished - Jul 2006
Externally publishedYes

Abstract

We describe a distinctive, widespread population of neurons situated beneath the pial surface of the human embryonic forebrain even before complete closure of the neural tube. These 'predecessor' cells include the first neurons seen in the primordium of the cerebral cortex, before the onset of local neurogenesis. Morphological analysis, combined with the study of centrosome location, regional transcription factors and patterns of mitosis and neurogenesis, indicates that predecessor cells invade the cortical primordium by tangential migration from the subpallium. These neurons, described here for the first time, precede all other known cell types of the developing cortex. © 2006 Nature Publishing Group.

Citation Format(s)

The first neurons of the human cerebral cortex. / Bystron, Irina; Rakic, Pasko; Molnár, Zoltán; Blakemore, Colin.

In: Nature Neuroscience, Vol. 9, No. 7, 07.2006, p. 880-886.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal