The first neurons of the human cerebral cortex
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
|Journal / Publication||Nature Neuroscience|
|Online published||18 Jun 2006|
|Publication status||Published - Jul 2006|
|Link to Scopus||https://www.scopus.com/record/display.uri?eid=2-s2.0-33745566385&origin=recordpage|
We describe a distinctive, widespread population of neurons situated beneath the pial surface of the human embryonic forebrain even before complete closure of the neural tube. These 'predecessor' cells include the first neurons seen in the primordium of the cerebral cortex, before the onset of local neurogenesis. Morphological analysis, combined with the study of centrosome location, regional transcription factors and patterns of mitosis and neurogenesis, indicates that predecessor cells invade the cortical primordium by tangential migration from the subpallium. These neurons, described here for the first time, precede all other known cell types of the developing cortex. © 2006 Nature Publishing Group.