The evolutionary dynamics of receptor binding avidity in influenza A : A mathematical model for a new antigenic drift hypothesis
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Journal / Publication | Philosophical Transactions of the Royal Society B: Biological Sciences |
Volume | 368 |
Issue number | 1614 |
Online published | 4 Feb 2013 |
Publication status | Published - 19 Mar 2013 |
Externally published | Yes |
Link(s)
Abstract
The most salient feature of influenza evolution in humans is its antigenic drift. This process is characterized by structural changes in the virus's Bcell epitopes and ultimately results in the ability of the virus to evade immune recognition and thereby reinfect previously infected hosts. Until recently, amino acid substitutions in epitope regions of the viral haemagglutinin were thought to be positively selected for their ability to reduce antibody binding and therefore were thought to be responsible for driving antigenic drift. However, a recent hypothesis put forward by Hensley and co-workers posits that cellular receptor binding avidity is the dominant phenotype under selection, with antigenic drift being a side effect of these binding avidity changes. Here, we present a mathematical formulation of this new antigenic drift model and use it to show how rates of antigenic drift depend on epidemiological parameters. We further use the model to evaluate how two different vaccination strategies can impact antigenic drift rates and ultimately disease incidence levels. Finally, we discuss the assumptions present in the model formulation, predictions of the model, and future work that needs to be done to determine the consistency of this hypothesis with known patterns of influenza's genetic and antigenic evolution.
Research Area(s)
- Antigenic drift, Binding avidity changes, Disease dynamics, Influenza evolution
Citation Format(s)
The evolutionary dynamics of receptor binding avidity in influenza A: A mathematical model for a new antigenic drift hypothesis. / Yuan, Hsiang-Yu; Koelle, Katia.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 368, No. 1614, 19.03.2013.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 368, No. 1614, 19.03.2013.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review