The evolution of gadolinium based contrast agents : from single-modality to multi-modality

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Ruiqing Liu
  • Hui Peng
  • Penghui Li
  • Zushun Xu
  • Andrew K. Whittaker

Detail(s)

Original languageEnglish
Pages (from-to)10491-10510
Journal / PublicationNanoscale
Volume8
Issue number20
Online published3 May 2016
Publication statusPublished - 28 May 2016
Externally publishedYes

Abstract

Gadolinium-based contrast agents are extensively used as magnetic resonance imaging (MRI) contrast agents due to their outstanding signal enhancement and ease of chemical modification. However, it is increasingly recognized that information obtained from single modal molecular imaging cannot satisfy the higher requirements on the efficiency and accuracy for clinical diagnosis and medical research, due to its limitation and default rooted in single molecular imaging technique itself. To compensate for the deficiencies of single function magnetic resonance imaging contrast agents, the combination of multi-modality imaging has turned to be the research hotpot in recent years. This review presents an overview on the recent developments of the functionalization of gadolinium-based contrast agents, and their application in biomedicine applications.

Citation Format(s)

The evolution of gadolinium based contrast agents : from single-modality to multi-modality. / Zhang, Li; Liu, Ruiqing; Peng, Hui; Li, Penghui; Xu, Zushun; Whittaker, Andrew K.

In: Nanoscale, Vol. 8, No. 20, 28.05.2016, p. 10491-10510.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review