The enteric virome of cats with feline panleukopenia differs in abundance and diversity from healthy cats

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

  • Kate Van Brussel
  • Mang Shi
  • Maura Carrai
  • Edward C. Holmes

Detail(s)

Original languageEnglish
Pages (from-to)e2952-e2966
Number of pages15
Journal / PublicationTransboundary and Emerging Diseases
Volume69
Issue number5
Online published29 Jun 2022
Publication statusPublished - Sept 2022

Link(s)

Abstract

Feline panleukopenia (FPL) is a severe, often fatal disease caused by feline panleukopenia virus (FPV). How infection with FPV might impact the composition of the entire eukaryotic enteric virome in cats has not been characterized. We used meta-transcriptomic and viral particle enrichment metagenomic approaches to characterize the enteric viromes of 23 cats naturally infected with FPV (FPV-cases) and 36 age-matched healthy shelter cats (healthy controls). Sequencing reads from mammalian infecting viral families largely belonged to the Coronaviridae, Parvoviridae and Astroviridae. The most abundant viruses among the healthy control cats were feline coronavirus, Mamastrovirus 2 and Carnivore bocaparvovirus 3 (feline bocavirus), with frequent coinfections of all three. Feline chaphamaparvovirus was only detected in healthy controls (6 out of 36, 16.7%). Among the FPV-cases, in addition to FPV, the most abundant viruses were Mamastrovirus 2, feline coronavirus and C. bocaparvovirus 4 (feline bocaparvovirus 2). The latter and feline bocaparvovirus 3 were detected significantly more frequently in FPV-cases than in healthy controls. Feline calicivirus was present in a higher proportion of FPV-cases (11 out of 23, 47.8%) compared to healthy controls (5 out of 36, 13.9%, p = 0.0067). Feline kobuvirus infections were also common among FPV-cases (9 out of 23, 39.1%) and were not detected in any healthy controls (p < .0001). While abundant in both groups, astroviruses were more frequently present in FPV-cases (19 out of 23, 82.6%) than in healthy controls (18 out of 36, p = .0142). The differences in eukaryotic virome composition revealed here indicate that further investigations are warranted to determine associations between enteric viral co-infections on clinical disease severity in cats with FPL.

Research Area(s)

  • co-infection, Feline calicivirus, feline kobuvirus, Feline panleukopenia virus, virome

Bibliographic Note

© 2022 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.

Citation Format(s)

The enteric virome of cats with feline panleukopenia differs in abundance and diversity from healthy cats. / Van Brussel, Kate; Wang, Xiuwan; Shi, Mang et al.
In: Transboundary and Emerging Diseases, Vol. 69, No. 5, 09.2022, p. e2952-e2966.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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