TY - JOUR
T1 - The emerging role of exosomes in Wnt secretion and transport
AU - Zhang, Liang
AU - Wrana, Jeffrey L.
PY - 2014/8
Y1 - 2014/8
N2 - Exosomes are small extracellular microvesicles that have an endosomal origin and are gaining increasing recognition for their important roles in mediating cell-cell communication. The content of exosomes includes a broad range of bioactive molecules, such as miRNA and signaling molecules that can mediate intercellular communication in various functional contexts. Recent studies have pointed to a critical role of exosomes in transmitting morphogen signaling during embryonic development and cancer progression. In this review we focus on recent progress that has revealed a role for exosomes in the secretion and processing of Wnt proteins, a family of morphogens with fundamental roles in homeostasis and cancer. © 2014 Elsevier Ltd.
AB - Exosomes are small extracellular microvesicles that have an endosomal origin and are gaining increasing recognition for their important roles in mediating cell-cell communication. The content of exosomes includes a broad range of bioactive molecules, such as miRNA and signaling molecules that can mediate intercellular communication in various functional contexts. Recent studies have pointed to a critical role of exosomes in transmitting morphogen signaling during embryonic development and cancer progression. In this review we focus on recent progress that has revealed a role for exosomes in the secretion and processing of Wnt proteins, a family of morphogens with fundamental roles in homeostasis and cancer. © 2014 Elsevier Ltd.
UR - http://www.scopus.com/inward/record.url?scp=84899806674&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84899806674&origin=recordpage
U2 - 10.1016/j.gde.2014.03.006
DO - 10.1016/j.gde.2014.03.006
M3 - RGC 62 - Review of books or of software (or similar publications/items)
C2 - 24791688
SN - 0959-437X
VL - 27
SP - 14
EP - 19
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -
