The emerging role of exosomes in Wnt secretion and transport

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)62_Review of books or of software (or similar publications/items)

39 Scopus Citations
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Detail(s)

Original languageEnglish
Pages (from-to)14-19
Journal / PublicationCurrent Opinion in Genetics and Development
Volume27
Publication statusPublished - Aug 2014
Externally publishedYes

Abstract

Exosomes are small extracellular microvesicles that have an endosomal origin and are gaining increasing recognition for their important roles in mediating cell-cell communication. The content of exosomes includes a broad range of bioactive molecules, such as miRNA and signaling molecules that can mediate intercellular communication in various functional contexts. Recent studies have pointed to a critical role of exosomes in transmitting morphogen signaling during embryonic development and cancer progression. In this review we focus on recent progress that has revealed a role for exosomes in the secretion and processing of Wnt proteins, a family of morphogens with fundamental roles in homeostasis and cancer. © 2014 Elsevier Ltd.