The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Yiran Wang; Mandi Wu; Yichen Li; Ho Him Yuen; Ming-Liang He

doi:10.1186/s12929-022-00811-4

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Yiran Wang
, Mandi Wu
, Yichen Li
, Ho Him Yuen
, Ming-Liang He^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

21 Citations (Scopus)

65 Downloads (CityUHK Scholars)

Abstract

The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies.

Original language	English
Article number	27
Journal	Journal of Biomedical Science
Volume	29
Online published	3 May 2022
DOIs	https://doi.org/10.1186/s12929-022-00811-4
Publication status	Published - 2022

Funding

The work was partially supported by grants from The Science Technology and Innovation Committee of Shenzhen Municipality [JCYJ20180507181627057]; RGC General Research Fund of Hong Kong Special Administrative Region [11104020] and Strategic funds from City University of Hong Kong.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

SARS-CoV-2
Innate immunity
Inflammatory response
Drug targets
NEUTROPHIL EXTRACELLULAR TRAPS
HOST GENE-EXPRESSION
I INTERFERON
CORONAVIRUS
SARS
CORTICOSTEROIDS
ACTIVATION
PROTEIN
CELLS
MACROPHAGES

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

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10.1186/s12929-022-00811-4

101167798.pdfFinal Published version, 1.7 MBLicence: CC BY

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Cite this

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abstract = "The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies.",

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year = "2022",

doi = "10.1186/s12929-022-00811-4",

language = "English",

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journal = "Journal of Biomedical Science",

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AU - Wu, Mandi

AU - Li, Yichen

AU - Yuen, Ho Him

AU - He, Ming-Liang

PY - 2022

Y1 - 2022

N2 - The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies.

AB - The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies.

KW - SARS-CoV-2

KW - Innate immunity

KW - Inflammatory response

KW - Drug targets

KW - NEUTROPHIL EXTRACELLULAR TRAPS

KW - HOST GENE-EXPRESSION

KW - I INTERFERON

KW - CORONAVIRUS

KW - SARS

KW - CORTICOSTEROIDS

KW - ACTIVATION

KW - PROTEIN

KW - CELLS

KW - MACROPHAGES

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M3 - RGC 21 - Publication in refereed journal

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ER -

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Abstract

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

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GRF: Structural Basis of Hsp27 in the Regulation of hnRNP A1 Protein Relocalization upon Enterovirus A71 Infection

Cite this

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Abstract

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Structural Basis of Hsp27 in the Regulation of hnRNP A1 Protein Relocalization upon Enterovirus A71 Infection

Cite this