The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Chi-Fai Chan; Chen Xie; Ming-Kiu Tsang; Sam Lear; Lixiong Dai; Yan Zhou; Jakub Cicho; Miroslaw Karbowiak; Dariusz Hreniak; Rongfeng Lan; Steve L. Cobb; Michael Hon-Wah Lam; Jianhua Hao; Ka-Leung Wong

doi:10.1002/ejic.201500321

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Chi-Fai Chan
, Chen Xie
, Ming-Kiu Tsang
, Sam Lear
, Lixiong Dai
, Yan Zhou
, Jakub Cicho
, Miroslaw Karbowiak
, Dariusz Hreniak^*
, Rongfeng Lan^*
, Steve L. Cobb
, Michael Hon-Wah Lam
, Jianhua Hao
, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

9 Citations (Scopus)

Abstract

In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF₄

Original language	English
Pages (from-to)	4539-4545
Journal	European Journal of Inorganic Chemistry
Volume	2015
Issue number	27
DOIs	https://doi.org/10.1002/ejic.201500321
Publication status	Published - 1 Sept 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Antitumor agents
Imaging agents
Inhibitors
Lanthanides
Medicinal chemistry
Nanoparticles
Peptides

Access Output

10.1002/ejic.201500321

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

Chan, C.-F., Xie, C., Tsang, M.-K., Lear, S., Dai, L., Zhou, Y., Cicho, J., Karbowiak, M., Hreniak, D., Lan, R., Cobb, S. L., Lam, M. H.-W., Hao, J., & Wong, K.-L. (2015). The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors. European Journal of Inorganic Chemistry, 2015(27), 4539-4545. https://doi.org/10.1002/ejic.201500321

@article{8d5e30baee4549889d3763485763fc5e,

title = "The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors",

abstract = "In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4",

keywords = "Antitumor agents, Imaging agents, Inhibitors, Lanthanides, Medicinal chemistry, Nanoparticles, Peptides",

author = "Chi-Fai Chan and Chen Xie and Ming-Kiu Tsang and Sam Lear and Lixiong Dai and Yan Zhou and Jakub Cicho and Miroslaw Karbowiak and Dariusz Hreniak and Rongfeng Lan and Cobb, \{Steve L.\} and Lam, \{Michael Hon-Wah\} and Jianhua Hao and Ka-Leung Wong",

year = "2015",

month = sep,

day = "1",

doi = "10.1002/ejic.201500321",

language = "English",

volume = "2015",

pages = "4539--4545",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag GmbH",

number = "27",

}

Chan, C-F, Xie, C, Tsang, M-K, Lear, S, Dai, L, Zhou, Y, Cicho, J, Karbowiak, M, Hreniak, D, Lan, R, Cobb, SL, Lam, MH-W, Hao, J & Wong, K-L 2015, 'The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors', European Journal of Inorganic Chemistry, vol. 2015, no. 27, pp. 4539-4545. https://doi.org/10.1002/ejic.201500321

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors. / Chan, Chi-Fai; Xie, Chen; Tsang, Ming-Kiu et al.
In: European Journal of Inorganic Chemistry, Vol. 2015, No. 27, 01.09.2015, p. 4539-4545.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

AU - Chan, Chi-Fai

AU - Xie, Chen

AU - Tsang, Ming-Kiu

AU - Lear, Sam

AU - Dai, Lixiong

AU - Zhou, Yan

AU - Cicho, Jakub

AU - Karbowiak, Miroslaw

AU - Hreniak, Dariusz

AU - Lan, Rongfeng

AU - Cobb, Steve L.

AU - Lam, Michael Hon-Wah

AU - Hao, Jianhua

AU - Wong, Ka-Leung

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4

AB - In this work, the shape effect of our same-sized hybrid nanomaterials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4

KW - Antitumor agents

KW - Imaging agents

KW - Inhibitors

KW - Lanthanides

KW - Medicinal chemistry

KW - Nanoparticles

KW - Peptides

UR - https://www.scopus.com/pages/publications/84942503790

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84942503790&origin=recordpage

U2 - 10.1002/ejic.201500321

DO - 10.1002/ejic.201500321

M3 - RGC 21 - Publication in refereed journal

SN - 1434-1948

VL - 2015

SP - 4539

EP - 4545

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 27

ER -

The Effects of Morphology and Linker Length on the Properties of Peptide-Lanthanide Upconversion Nanomaterials as G2 Phase Cell Cycle Inhibitors

Abstract

UN SDGs

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this