The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 211-217 |
Journal / Publication | Biochemical and Biophysical Research Communications |
Volume | 145 |
Issue number | 1 |
Publication status | Published - 29 May 1987 |
Externally published | Yes |
Link(s)
Abstract
Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes. © 1987.
Citation Format(s)
The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes. / Marton, Attila; Sukosd-Rozlosnik, Noemi; Vertes, Attila et al.
In: Biochemical and Biophysical Research Communications, Vol. 145, No. 1, 29.05.1987, p. 211-217.
In: Biochemical and Biophysical Research Communications, Vol. 145, No. 1, 29.05.1987, p. 211-217.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review