The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes

Attila Marton; Noemi Sukosd-Rozlosnik; Attila Vertes; Istvan Horvath

doi:10.1016/0006-291X(87)91308-8

The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes

Attila Marton, Noemi Sukosd-Rozlosnik, Attila Vertes, Istvan Horvath

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes. © 1987.

Original language	English
Pages (from-to)	211-217
Journal	Biochemical and Biophysical Research Communications
Volume	145
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(87)91308-8
Publication status	Published - 29 May 1987
Externally published	Yes

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title = "The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes",

abstract = "Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes. {\textcopyright} 1987.",

author = "Attila Marton and Noemi Sukosd-Rozlosnik and Attila Vertes and Istvan Horvath",

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The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes. / Marton, Attila; Sukosd-Rozlosnik, Noemi; Vertes, Attila et al.
In: Biochemical and Biophysical Research Communications, Vol. 145, No. 1, 29.05.1987, p. 211-217.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes

AU - Marton, Attila

AU - Sukosd-Rozlosnik, Noemi

AU - Vertes, Attila

AU - Horvath, Istvan

PY - 1987/5/29

Y1 - 1987/5/29

N2 - Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes. © 1987.

AB - Unlike EDTA-Fe(III) (1:1), the oxidized form of EDTA-Fe(II) complex enhanced lipid peroxidation in brain microsomes. Mossbauer spectroscopy and electron paramagnetic resonance analysis of oxidized EDTA-Fe(II), capable of inducing lipid peroxidation, showed the presence of EDTA-Fe(III) complex, which was different from the separately prepared (not oxidized) EDTA-Fe(III). Lipid peroxidation initiated by the oxidized EDTA-Fe(II) complex was dependent on the presence of NAD(P)H and functionally intact microsomes. No inhibitory effect was found by generally used free radical scavengers and catalase. Our results clearly indicate that the chemically different EDTA-Fe(III) complexes differ in their capability of initiating the NAD(P)H-dependent lipid peroxidation in brain microsomes. © 1987.

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U2 - 10.1016/0006-291X(87)91308-8

DO - 10.1016/0006-291X(87)91308-8

M3 - RGC 21 - Publication in refereed journal

C2 - 3036119

SN - 0006-291X

VL - 145

SP - 211

EP - 217

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

The effect of EDTA-Fe(III) complexes with different chemical structure on the lipid peroxidation in brain microsomes

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