The development of RAPTA compounds for the treatment of tumors

Benjamin S. Murray; Maria V. Babak; Christian G. Hartinger; Paul J. Dyson

doi:10.1016/j.ccr.2015.06.014

The development of RAPTA compounds for the treatment of tumors

Benjamin S. Murray
, Maria V. Babak
, Christian G. Hartinger
, Paul J. Dyson^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

450 Citations (Scopus)

Abstract

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

Original language	English
Pages (from-to)	86-114
Journal	Coordination Chemistry Reviews
Volume	306
Issue number	1
Online published	7 Jul 2015
DOIs	https://doi.org/10.1016/j.ccr.2015.06.014
Publication status	Published - 1 Jan 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Angiogenesis
Bioorganometallic chemistry
Cancer
Metastasis
RAPTA

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@article{3dc32fb372ed430dac35e0540ade8536,

title = "The development of RAPTA compounds for the treatment of tumors",

abstract = "Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.",

keywords = "Angiogenesis, Bioorganometallic chemistry, Cancer, Metastasis, RAPTA, Angiogenesis, Bioorganometallic chemistry, Cancer, Metastasis, RAPTA, Angiogenesis, Bioorganometallic chemistry, Cancer, Metastasis, RAPTA",

author = "Murray, \{Benjamin S.\} and Babak, \{Maria V.\} and Hartinger, \{Christian G.\} and Dyson, \{Paul J.\}",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.ccr.2015.06.014",

language = "English",

volume = "306",

pages = "86--114",

journal = "Coordination Chemistry Reviews",

issn = "0010-8545",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - The development of RAPTA compounds for the treatment of tumors

AU - Murray, Benjamin S.

AU - Babak, Maria V.

AU - Hartinger, Christian G.

AU - Dyson, Paul J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

AB - Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

KW - Angiogenesis

KW - Bioorganometallic chemistry

KW - Cancer

KW - Metastasis

KW - RAPTA

KW - Angiogenesis

KW - Bioorganometallic chemistry

KW - Cancer

KW - Metastasis

KW - RAPTA

KW - Angiogenesis

KW - Bioorganometallic chemistry

KW - Cancer

KW - Metastasis

KW - RAPTA

UR - https://www.scopus.com/pages/publications/84982077068

UR - https://www.scopus.com/pages/publications/84982077068#tab=impact

U2 - 10.1016/j.ccr.2015.06.014

DO - 10.1016/j.ccr.2015.06.014

M3 - RGC 21 - Publication in refereed journal

SN - 0010-8545

VL - 306

SP - 86

EP - 114

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

IS - 1

ER -

The development of RAPTA compounds for the treatment of tumors

Abstract

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Research Keywords

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